LACTB2 Gene

Name	lactamase, beta 2
Description	Enables RNA endonuclease activity; single-stranded RNA binding activity; and zinc ion binding activity. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LACTB2 is a mitochondrial metallo‐β‐lactamase domain protein that functions as a robust endoribonuclease involved in the turnover of mitochondrial RNA. Structural and biochemical studies have demonstrated that LACTB2 aligns closely with other MBL superfamily ribonucleases, such as CPSF73, and exhibits a strong preference for cleaving single‐stranded RNA after purine–pyrimidine sequences; mutation of key residues within an extended RNA‐binding site impairs its activity, and manipulation of its expression levels in cultured human cells leads to significant changes in mitochondrial transcript abundance and cell viability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, LACTB2 has been implicated in cancer biology; a recurrent fusion transcript involving LACTB2 and NCOA2 has been detected in colorectal cancer, suggesting that genomic rearrangements affecting LACTB2—although resulting in structurally amorphic fusion proteins—may contribute to tumorigenesis by disrupting normal regulatory functions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, in nasopharyngeal carcinoma, LACTB2 expression is upregulated following radiotherapy and its interaction with the N-terminal domain of PINK1 appears to trigger PINK1-dependent mitophagy, a process that promotes radioresistance; these findings indicate that overexpressed LACTB2 serves as a potential prognostic biomarker and therapeutic target in this setting."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Beyond its role in human disease, LACTB2 has emerged as a candidate gene in diverse biological contexts: its differential expression has been mapped to a major quantitative trait locus for salinity tolerance in tilapia, hinting at a role in environmental stress responses"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", while genetic association studies in humans have linked loci encompassing LACTB2 to variations in erythrocyte cadmium levels, suggesting involvement in metal absorption and metabolism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In addition, altered LACTB2 expression has been observed during liver regeneration"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "and in the diabetic glomerulus, underscoring its potential relevance in tissue homeostasis and the response to cellular stress."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies position LACTB2 as a multifunctional protein essential for mitochondrial RNA processing and proper organelle function, while also implicating it in mechanisms underlying cancer progression, stress adaptation, and metabolic regulation.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shiri Levy, Charles K Allerston, Varda Liveanu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of LACTB2, a metallo-β-lactamase protein, as a human mitochondrial endoribonuclease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkw050"}], "href": "https://doi.org/10.1093/nar/gkw050"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26826708"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26826708"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "J Yu, W K K Wu, Q Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disruption of NCOA2 by recurrent fusion with LACTB2 in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2015.72"}], "href": "https://doi.org/10.1038/onc.2015.72"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25823027"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25823027"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Qianping Chen, Wang Zheng, Lin Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LACTB2 renders radioresistance by activating PINK1/Parkin-dependent mitophagy in nasopharyngeal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2021.07.019"}], "href": "https://doi.org/10.1016/j.canlet.2021.07.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34271102"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34271102"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiao Hui Gu, Dan Li Jiang, Yan Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identifying a Major QTL Associated with Salinity Tolerance in Nile Tilapia Using QTL-Seq."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mar Biotechnol (NY) (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10126-017-9790-4"}], "href": "https://doi.org/10.1007/s10126-017-9790-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29318417"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29318417"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yan Borné, Martin Söderholm, Lars Barregard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome wide association study identifies two loci associated with cadmium in erythrocytes among never-smokers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddw083"}], "href": "https://doi.org/10.1093/hmg/ddw083"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27005419"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27005419"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hui-Chu Hsieh, Yi-Ting Chen, Jen-Ming Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein profilings in mouse liver regeneration after partial hepatectomy using iTRAQ technology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteome Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/pr800696m"}], "href": "https://doi.org/10.1021/pr800696m"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19099420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19099420"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yung-Chien Hsu, Chen-Chou Lei, Cheng Ho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Potential biomarkers associated with diabetic glomerulopathy through proteomics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ren Fail (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/0886022X.2015.1077321"}], "href": "https://doi.org/10.3109/0886022X.2015.1077321"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26364511"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26364511"}]}]}]}
Synonyms	CGI-83
Proteins	LACB2_HUMAN
NCBI Gene ID	51110
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

LACTB2 has 6,251 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 110 datasets.

Click the + buttons to view associations for LACTB2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

LACTB2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LACTB2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of LACTB2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of LACTB2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of LACTB2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of LACTB2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LACTB2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of LACTB2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of LACTB2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of LACTB2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of LACTB2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of LACTB2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with LACTB2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with LACTB2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LACTB2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of LACTB2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of LACTB2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of LACTB2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing LACTB2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing LACTB2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing LACTB2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with LACTB2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of LACTB2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with LACTB2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with LACTB2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with LACTB2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of LACTB2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by LACTB2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with LACTB2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with LACTB2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with LACTB2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with LACTB2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at LACTB2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LACTB2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of LACTB2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing LACTB2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of LACTB2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing LACTB2 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of LACTB2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of LACTB2 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of LACTB2 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.