{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent transcriptomic analyses have identified the long noncoding RNA LAMA5‐AS1 as a potential prognostic biomarker in diverse tumor types. In osteosarcoma, LAMA5‐AS1 was one component of a five‐lncRNA signature that significantly distinguished patient survival outcomes, with its altered expression correlating with overall survival and suggesting a potential role in tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in multiple myeloma, dysregulated LAMA5‐AS1 expression has been found to associate with advanced disease stage, higher risk status, and poorer overall survival, indicating that it may contribute to the malignant phenotype and could serve as a candidate molecular marker for prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Although the precise molecular mechanisms underlying LAMA5‐AS1’s function remain to be fully elucidated, its integration in prognostic signatures across tumor types underscores its potential involvement in oncogenic regulatory networks and highlights its promise as a target for future therapeutic intervention.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "SiYuan Yu, FengLing Shao, HuiJun Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A five metastasis-related long noncoding RNA risk signature for osteosarcoma survival prediction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genomics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12920-021-00972-5"}], "href": "https://doi.org/10.1186/s12920-021-00972-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33964903"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33964903"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ying Shen, Yuandong Feng, Hongli Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Focusing on long non-coding RNA dysregulation in newly diagnosed multiple myeloma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lfs.2018.01.025"}], "href": "https://doi.org/10.1016/j.lfs.2018.01.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29459023"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29459023"}]}]}]}