{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LAMTOR5‐AS1 is a long non‑coding RNA with multifaceted regulatory roles in cancer. In colorectal cancer, although its overall expression does not markedly differ between tumor and non‑tumor tissues, LAMTOR5‑AS1 shows significant upregulation in elderly patients and is positively correlated with its neighboring gene LAMTOR5, which itself is overexpressed and associated with diagnostic potential. This association is partly explained by LAMTOR5‑AS1’s predicted ability to “sponge” miRNAs (hsa‑miR‑let‑7b‑3p and hsa‑miR‑20a‑5p) that are involved in overall survival and disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In non‑small cell lung cancer, LAMTOR5‑AS1 is significantly overexpressed and correlates with poor prognosis. Functional studies demonstrated that its knockdown suppresses cell proliferation, cloning, and metastasis while promoting apoptosis. Mechanistically, LAMTOR5‑AS1 acts as a sponge for miR‑506‑3p, thereby de‐repressing the expression of E2F6, a transcription factor that contributes to tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In prostate cancer, increased expression of LAMTOR5‑AS1 in fine needle aspiration biopsies has been linked to aggressive disease features. Its regulatory network appears to involve interactions with miRNAs (including miR‑942‑5p and miR‑542‑3p) as part of competing endogenous RNA (ceRNA) mechanisms that may modulate key cancer‑related pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In osteosarcoma, higher levels of LAMTOR5‑AS1 are observed in chemosensitive cell lines compared to chemoresistant ones. Here, LAMTOR5‑AS1 suppresses cell proliferation and multidrug resistance by mediating the interaction between NRF2 and KEAP1. It protects NRF2 from ubiquitination‐mediated degradation, resulting in NRF2 accumulation (albeit with reduced transcriptional activity) and subsequent regulation of downstream effectors such as HO‑1. This pathway modulates chemotherapy‑induced oxidative stress and underscores the potential of LAMTOR5‑AS1 as a target to overcome drug resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies indicate that LAMTOR5‑AS1 functions as a key regulatory molecule in various cancers by modulating miRNA activity and critical signaling pathways associated with proliferation, metastasis, oxidative stress, and drug resistance.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Najmeh Riahi Zaniani, Andisheh Oroujalian, Ali Valipour, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LAMTOR5 expression level is a biomarker for colorectal cancer and lncRNA LAMTOR5-AS1 predicting miRNA sponging effect."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-021-06623-3"}], "href": "https://doi.org/10.1007/s11033-021-06623-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34374893"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34374893"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Guojie Chen, Kai Wang, Guoshu Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA LAMTOR5-AS1 Interference Affects MicroRNA-506-3p/E2F6-Mediated Behavior of Non-Small Cell Lung Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3727/096504021X16328213967104"}], "href": "https://doi.org/10.3727/096504021X16328213967104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34588094"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34588094"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zehuan Li, Jianghua Zheng, Qianlin Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Specific Long Non-Coding Ribonucleic Acid Signatures and Regulatory Networks in Prostate Cancer in Fine-Needle Aspiration Biopsies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2020.00062"}], "href": "https://doi.org/10.3389/fgene.2020.00062"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32117463"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32117463"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Youguang Pu, Yiao Tan, Chunbao Zang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LAMTOR5-AS1 regulates chemotherapy-induced oxidative stress by controlling the expression level and transcriptional activity of NRF2 in osteosarcoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-04413-0"}], "href": "https://doi.org/10.1038/s41419-021-04413-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34862368"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34862368"}]}]}]}