{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent work on pediatric acute myelocytic leukemia (AML) has highlighted the prognostic value of long non‐coding RNAs. In one study, RNA‐sequencing data from 111 children were analyzed to identify differentially expressed lncRNAs between poor and favorable prognosis groups, leading to the construction of a 14‐lncRNA risk score system for predicting AML outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Among these lncRNAs, LARS2-AS1 was found to regulate semaphorin-3C (SEMA3C), a gene implicated in the axon guidance pathway. This regulatory axis suggests that LARS2-AS1 may contribute to AML progression by affecting axon guidance mechanisms—a pathway that may significantly influence patient prognosis. These findings underscore the potential of targeting LARS2-AS1-mediated pathways for improving prognostic prediction and therapeutic strategies in AML."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shuli Guo, Bo Li, Xiaoyan Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction of a 14-lncRNA risk score system predicting survival of children with acute myelocytic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Ther Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/etm.2020.8846"}], "href": "https://doi.org/10.3892/etm.2020.8846"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32742384"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32742384"}]}]}]}