LASP1 Gene

Name	LIM and SH3 protein 1
Description	This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LASP1 is an actin‐binding scaffold protein that localizes to focal adhesions and the leading edges of migrating cells, where it regulates cytoskeletal dynamics and cell motility."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " In several cancer types—including breast, colorectal, ovarian, bladder, prostate, hepatocellular, and esophageal carcinomas—overexpression of LASP1 is associated with enhanced proliferation, migration, invasion, and epithelial–mesenchymal transition, which contribute to tumor aggressiveness and poor patient outcome."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "9"}]}, {"type": "t", "text": " In addition, tumor‐suppressive microRNAs such as miR‑1, miR‑133a, miR‑203, and miR‑218 as well as the transcription factor p53 negatively regulate LASP1 expression, thereby limiting cancer cell motility and invasive behavior."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "15"}]}, {"type": "t", "text": " Furthermore, LASP1 undergoes phosphorylation‐dependent regulation that affects its subcellular localization, and it interacts with proteins such as zyxin and LIM‐nebulette to coordinate focal adhesion turnover and actin filament assembly."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": " LASP1 also contributes to specific signaling pathways: its binding to the carboxy‐terminal domain of chemokine receptors (for example, CXCR2) is essential for directed chemotaxis in immune cells"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": ", while its interaction with S100A11 links it to TGFβ‐mediated epithelial–mesenchymal transition in colorectal cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": " Finally, LASP1 functions as a cytoskeletal adaptor in non‐transformed cells, as evidenced by its role in vasopressin‐induced actin remodeling in kidney collecting duct cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": " Collectively, these findings underscore the multifaceted role of LASP1 in regulating actin cytoskeleton organization, cell migration, and signaling, thereby highlighting its potential as both a biomarker and a therapeutic target in cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yi Hsing Lin, Zee-Yong Park, Dayin Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of cell migration and survival by focal adhesion targeting of Lasp-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200311045"}], "href": "https://doi.org/10.1083/jcb.200311045"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15138294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15138294"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Catherine S Chew, Xunsheng Chen, John A Parente, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lasp-1 binds to non-muscle F-actin in vitro and is localized within multiple sites of dynamic actin assembly in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.00174"}], "href": "https://doi.org/10.1242/jcs.00174"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12432067"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12432067"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Thomas G P Grunewald, Ulrike Kammerer, Elfriede Schulze, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of LASP-1 influences zyxin localization, inhibits proliferation and reduces migration in breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2005.12.016"}], "href": "https://doi.org/10.1016/j.yexcr.2005.12.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16430883"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16430883"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Christian Keicher, Stepan Gambaryan, Elfriede Schulze, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2004.08.235"}], "href": "https://doi.org/10.1016/j.bbrc.2004.08.235"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15465019"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15465019"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Liang Zhao, Hui Wang, Chao Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Promotion of colorectal cancer growth and metastasis by the LIM and SH3 domain protein 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gut (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/gut.2009.202739"}], "href": "https://doi.org/10.1136/gut.2009.202739"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20660701"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20660701"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "T G P Grunewald, U Kammerer, C Winkler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of LASP-1 mediates migration and proliferation of human ovarian cancer cells and influences zyxin localisation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.bjc.6603545"}], "href": "https://doi.org/10.1038/sj.bjc.6603545"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17211471"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17211471"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Hui Wang, Hongying An, Bin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-133a represses tumour growth and metastasis in colorectal cancer by targeting LIM and SH3 protein 1 and inhibiting the MAPK pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Cancer (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejca.2013.07.149"}], "href": "https://doi.org/10.1016/j.ejca.2013.07.149"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23968734"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23968734"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hui Wang, Jiaolong Shi, Yuhao Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LIM and SH3 protein 1 induces TGFβ-mediated epithelial-mesenchymal transition in human colorectal cancer by regulating S100A4 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-14-0485"}], "href": "https://doi.org/10.1158/1078-0432.CCR-14-0485"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25252758"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25252758"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "J J Frietsch, T G P Grunewald, S Jasper, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear localisation of LASP-1 correlates with poor long-term survival in female breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.bjc.6605685"}], "href": "https://doi.org/10.1038/sj.bjc.6605685"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20461080"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20461080"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Giuditta Viticchiè, Anna Maria Lena, Alessia Latina, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-203 controls proliferation, migration and invasive potential of prostate cancer cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.10.7.15180"}], "href": "https://doi.org/10.4161/cc.10.7.15180"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21368580"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21368580"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Chen Wang, Xiangqian Zheng, Chunyan Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-203 suppresses cell proliferation and migration by targeting BIRC5 and LASP1 in human triple-negative breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1756-9966-31-58"}], "href": "https://doi.org/10.1186/1756-9966-31-58"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22713668"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22713668"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Takeshi Chiyomaru, Hideki Enokida, Kazumori Kawakami, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional role of LASP1 in cell viability and its regulation by microRNAs in bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Urol Oncol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.urolonc.2010.05.008"}], "href": "https://doi.org/10.1016/j.urolonc.2010.05.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20843712"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20843712"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Rika Nishikawa, Yusuke Goto, Shinichi Sakamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor-suppressive microRNA-218 inhibits cancer cell migration and invasion via targeting of LASP1 in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.12441"}], "href": "https://doi.org/10.1111/cas.12441"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24815849"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24815849"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Bei Wang, Ziwei Xiao, Ee Chee Ren "}, {"type": "b", "children": [{"type": "t", "text": "Redefining the p53 response element."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0903284106"}], "href": "https://doi.org/10.1073/pnas.0903284106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19597154"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19597154"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yan-Yan Du, Lian-Mei Zhao, Liang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The tumor-suppressive function of miR-1 by targeting LASP1 and TAGLN2 in esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gastroenterol Hepatol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jgh.13180"}], "href": "https://doi.org/10.1111/jgh.13180"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26414725"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26414725"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Bo Li, Lei Zhuang, Beat Trueb "}, {"type": "b", "children": [{"type": "t", "text": "Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M310304200"}], "href": "https://doi.org/10.1074/jbc.M310304200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15004028"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15004028"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Dayanidhi Raman, Jiqing Sai, Nicole F Neel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LIM and SH3 protein-1 modulates CXCR2-mediated cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0010050"}], "href": "https://doi.org/10.1371/journal.pone.0010050"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20419088"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20419088"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Ya Niu, Ziyun Shao, Hui Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LASP1-S100A11 axis promotes colorectal cancer aggressiveness by modulating TGFβ/Smad signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep26112"}], "href": "https://doi.org/10.1038/srep26112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27181092"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27181092"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Chin-San Loo, Cheng-Wei Chen, Po-Jen Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Quantitative apical membrane proteomics reveals vasopressin-induced actin dynamics in collecting duct cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1309219110"}], "href": "https://doi.org/10.1073/pnas.1309219110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24085853"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24085853"}]}]}]}
Synonyms	LASP-1, MLN50
Proteins	LASP1_HUMAN
NCBI Gene ID	3927
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

LASP1 has 10,561 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 132 datasets.

Click the + buttons to view associations for LASP1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

LASP1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LASP1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of LASP1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of LASP1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of LASP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of LASP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LASP1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of LASP1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of LASP1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of LASP1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of LASP1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of LASP1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of LASP1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with LASP1 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with LASP1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with LASP1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LASP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of LASP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of LASP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of LASP1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of LASP1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing LASP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing LASP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing LASP1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing LASP1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with LASP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with LASP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of LASP1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with LASP1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with LASP1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with LASP1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of LASP1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by LASP1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with LASP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with LASP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with LASP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with LASP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at LASP1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LASP1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of LASP1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing LASP1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.