{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In gastric cancer (GC), the long non‐coding RNA LATS2‐AS1–001 appears to function as a tumor suppressor. Specifically, its expression is significantly reduced in GC tissues, where it correlates strongly with lower levels of the tumor suppressor LATS2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Functional studies have demonstrated that ectopic overexpression of LATS2‐AS1–001 not only decreases cell viability and induces G0/G1 cell cycle arrest but also inhibits cell migration and invasion. Mechanistically, LATS2‐AS1–001 exerts its suppressive effects by binding to EZH2, which results in the upregulation of LATS2 and subsequent induction of YAP1 phosphorylation—a modification known to attenuate the oncogenic signaling of YAP1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, data from other studies have shown that in GC, upregulation of YAP1 (along with other oncogenic factors) is associated with enhanced proliferation, migration, and invasion, as well as poor prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Thus, LATS2‐AS1–001 acts as a critical molecular brake in GC by promoting the activation of tumor-suppressive signals (via LATS2 and YAP1 phosphorylation) and counteracting the oncogenic drive mediated by YAP1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dan Sun, Ying Wang, Huan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The novel long non-coding RNA LATS2-AS1-001 inhibits gastric cancer progression by regulating the LATS2/YAP1 signaling pathway via binding to EZH2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-020-01285-w"}], "href": "https://doi.org/10.1186/s12935-020-01285-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32514249"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32514249"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Dan Sun, Xiaoting Li, Yingjian He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "YAP1 enhances cell proliferation, migration, and invasion of gastric cancer in vitro and in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.13188"}], "href": "https://doi.org/10.18632/oncotarget.13188"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27835600"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27835600"}]}]}]}