LCE3B Gene

HGNC Family	Late cornified envelope proteins (LCE)
Name	late cornified envelope 3B
Description	Involved in defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; and killing of cells of another organism. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Late cornified envelope protein 3B (LCE3B) is a member of the LCE gene family located within the epidermal differentiation complex that plays a crucial role in maintaining and restoring skin barrier function. In normal epidermis, LCE3B is part of a group of proteins that are upregulated in response to barrier disruption or injury, thereby promoting barrier repair processes. Moreover, genetic studies have consistently shown that a common deletion encompassing LCE3B together with its neighbor LCE3C is associated with an increased risk of psoriasis. This deletion is thought to impair the normal compensatory mechanisms required for effective barrier repair and may also affect local antimicrobial defense by altering the expression profiles of related LCE proteins, with potential impacts on skin and oral microbiota composition. Together, these observations point to a central role for LCE3B in coordinating epidermal differentiation, preserving barrier integrity, and modulating innate immune responses that link skin barrier defects to psoriasis pathogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rafael de Cid, Eva Riveira-Munoz, Patrick L J M Zeeuwen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.313"}], "href": "https://doi.org/10.1038/ng.313"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19169253"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19169253"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Judith G M Bergboer, Geuranne S Tjabringa, Marijke Kamsteeg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Psoriasis risk genes of the late cornified envelope-3 group are distinctly expressed compared with genes of other LCE groups."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2010.12.017"}], "href": "https://doi.org/10.1016/j.ajpath.2010.12.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21435436"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21435436"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hanna Niehues, Danique A van der Krieken, Thomas H A Ederveen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antimicrobial Late Cornified Envelope Proteins: The Psoriasis Risk Factor Deletion of LCE3B/C Genes Affects Microbiota Composition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jid.2021.11.036"}], "href": "https://doi.org/10.1016/j.jid.2021.11.036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34942199"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34942199"}]}]}]}
Synonyms	LEP14
Proteins	LCE3B_HUMAN
NCBI Gene ID	353143
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

LCE3B has 944 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 46 datasets.

Click the + buttons to view associations for LCE3B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

LCE3B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LCE3B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of LCE3B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of LCE3B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LCE3B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of LCE3B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LCE3B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of LCE3B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of LCE3B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with LCE3B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with LCE3B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CTD Gene-Disease Associations	diseases associated with LCE3B gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by LCE3B gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with LCE3B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with LCE3B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with LCE3B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with LCE3B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at LCE3B gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LCE3B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of LCE3B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing LCE3B from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with LCE3B gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with LCE3B gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of LCE3B gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of LCE3B gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of LCE3B gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	transcription factor perturbations changing expression of LCE3B gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Viral Infections	virus perturbations changing expression of LCE3B gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
	GO Biological Process Annotations 2015	biological processes involving LCE3B gene from the curated GO Biological Process Annotations 2015 dataset.
	GO Biological Process Annotations 2023	biological processes involving LCE3B gene from the curated GO Biological Process Annotations 2023 dataset.
	GO Biological Process Annotations 2025	biological processes involving LCE3B gene from the curated GO Biological Process Annotations2025 dataset.
	GWAS Catalog SNP-Phenotype Associations 2025	phenotypes associated with LCE3B gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	cell lines with high or low expression of LCE3B gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
	HuGE Navigator Gene-Phenotype Associations	phenotypes associated with LCE3B gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
	InterPro Predicted Protein Domain Annotations	protein domains predicted for LCE3B protein from the InterPro Predicted Protein Domain Annotations dataset.
	JASPAR Predicted Human Transcription Factor Targets 2025	transcription factors regulating expression of LCE3B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
	JASPAR Predicted Transcription Factor Targets	transcription factors regulating expression of LCE3B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
	KEGG Pathways 2026	pathways involving LCE3B protein from the KEGG Pathways 2026 dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	cell lines with high or low copy number of LCE3B gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	transcription factor perturbations changing expression of LCE3B gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
	LOCATE Predicted Protein Localization Annotations	cellular components predicted to contain LCE3B protein from the LOCATE Predicted Protein Localization Annotations dataset.
	MotifMap Predicted Transcription Factor Targets	transcription factors regulating expression of LCE3B gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
	Reactome Pathways 2024	pathways involving LCE3B protein from the Reactome Pathways 2024 dataset.
	Rummagene Transcription Factor Associations 2026	transcription factors regulating expression of LCE3B gene from the Rummagene Transcription Factor Associations 2026 dataset.
	TCGA Signatures of Differentially Expressed Genes for Tumors	tissue samples with high or low expression of LCE3B gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
	TISSUES Text-mining Tissue Protein Expression Evidence Scores	tissues co-occuring with LCE3B protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.
	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	tissues co-occuring with LCE3B protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.