{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent investigations applying cutting‐edge genomic and machine learning methods have begun to reveal potential novel roles for noncoding RNAs such as LCMT1‐AS2. In one study focused on system toxicology, robust gene signatures were derived from gene expression data to classify cigarette smoke exposure and cessation in humans. Among the six novel genes predicted for their potential as biomarkers, LCMT1‐AS2 emerged as a candidate worthy of further study as an indicator of tobacco exposure."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In parallel, single‐cell transcriptomic analyses of first‐trimester human placental and decidual tissues have provided detailed maps of cellular heterogeneity and intercellular communication in the fetomaternal interface. Although this study primarily focused on defining cell types and deciphering regulatory interactions within early gestational tissues, the comprehensive dataset sets the stage for future work to explore the functional roles of candidate regulatory elements—including LCMT1‐AS2—in placental development and related pathologies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Maurizio Giordano, Kumar Parijat Tripathi, Mario Rosario Guarracino "}, {"type": "b", "children": [{"type": "t", "text": "Ensemble of rankers for efficient gene signature extraction in smoke exposure classification."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Bioinformatics (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12859-018-2035-3"}], "href": "https://doi.org/10.1186/s12859-018-2035-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29536823"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29536823"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hemant Suryawanshi, Pavel Morozov, Alexander Straus, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A single-cell survey of the human first-trimester placenta and decidua."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Adv (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/sciadv.aau4788"}], "href": "https://doi.org/10.1126/sciadv.aau4788"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30402542"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30402542"}]}]}]}