| Name | lipid droplet assembly factor 1 |
| Description | Involved in lipid droplet formation. Located in endoplasmic reticulum membrane and lipid droplet. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Lipid droplet (LD) biogenesis is orchestrated at the endoplasmic reticulum (ER) by a specialized protein machinery in which lipid droplet assembly factor 1 (LDAF1), formerly known as TMEM159 or promethin, plays a central role. LDAF1 forms a stable, approximately 600‐kDa complex with seipin, thereby defining the sites of LD formation and efficiently recruiting triacylglycerols (TAGs) to seed nascent droplets."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " Once LDs form, LDAF1 dissociates from seipin and relocates to the LD surface, ensuring proper maturation of the organelle. In addition to its core role in LD assembly, increased expression of LDAF1 has been observed under lipid storage conditions such as PPARγ‐induced hepatic adipogenesis, suggesting that it contributes to adipocyte differentiation and lipid homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Intriguingly, an LDAF1 (promethin) domain has been identified within viral RNA polymerases, implying that similar membrane‐anchoring modules might extend to viral replication strategies by targeting lipid microenvironments."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Finally, genome‐wide association studies have linked variation in TMEM159 expression to altered arousal states and an increased risk for major depressive disorder, highlighting a potential role for LDAF1 in modulating neural as well as metabolic processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jeeyun Chung, Xudong Wu, Talley J Lambert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LDAF1 and Seipin Form a Lipid Droplet Assembly Complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2019.10.006"}], "href": "https://doi.org/10.1016/j.devcel.2019.10.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31708432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31708432"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Inês G Castro, Michal Eisenberg-Bord, Elisa Persiani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Promethin Is a Conserved Seipin Partner Protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells8030268"}], "href": "https://doi.org/10.3390/cells8030268"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30901948"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30901948"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Maria Bohnert "}, {"type": "b", "children": [{"type": "t", "text": "New friends for seipin - Implications of seipin partner proteins in the life cycle of lipid droplets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Semin Cell Dev Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.semcdb.2020.04.012"}], "href": "https://doi.org/10.1016/j.semcdb.2020.04.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32402516"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32402516"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Joel M Goodman "}, {"type": "b", "children": [{"type": "t", "text": "LDAF1 Holds the Key to Seipin Function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2019.11.009"}], "href": "https://doi.org/10.1016/j.devcel.2019.11.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31794714"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31794714"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Songtao Yu, Navin Viswakarma, Surinder K Batra, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of promethin and PGLP as two novel up-regulated genes in PPARgamma1-induced adipogenic mouse liver."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochimie (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biochi.2004.09.015"}], "href": "https://doi.org/10.1016/j.biochi.2004.09.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15589683"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15589683"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ergin Sahin, Emre Keskin, Ilgaz Akata "}, {"type": "b", "children": [{"type": "t", "text": "The unique genome organization of two novel fusariviruses hosted by the true morel mushroom Morchella esculenta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virus Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.virusres.2021.198486"}], "href": "https://doi.org/10.1016/j.virusres.2021.198486"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34146607"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34146607"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Kening Li, Yuxin Du, Dong-Qing Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CEBPE expression is an independent prognostic factor for acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-019-1944-x"}], "href": "https://doi.org/10.1186/s12967-019-1944-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31164135"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31164135"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Philippe Jawinski, Holger Kirsten, Christian Sander, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human brain arousal in the resting state: a genome-wide association study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41380-018-0052-2"}], "href": "https://doi.org/10.1038/s41380-018-0052-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29703947"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29703947"}]}]}]}
|
| NCBI Gene ID | 57146 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
LDAF1 has 1,829 functional associations with biological entities spanning 6 categories (chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 27 datasets.
Click the + buttons to view associations for LDAF1 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of LDAF1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of LDAF1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with LDAF1 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of LDAF1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| CM4AI U2OS Cell Map Protein Localization Assemblies | assemblies containing LDAF1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing LDAF1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with LDAF1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving LDAF1 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing LDAF1 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of LDAF1 gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of LDAF1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of LDAF1 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by LDAF1 gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of LDAF1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of LDAF1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of LDAF1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of LDAF1 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of LDAF1 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of LDAF1 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of LDAF1 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of LDAF1 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of LDAF1 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Sci-Plex Drug Perturbation Signatures | drug perturbations changing expression of LDAF1 gene from the Sci-Plex Drug Perturbation Signatures dataset. | |
| Tahoe Therapeutics Tahoe 100M Perturbation Atlas | drug perturbations changing expression of LDAF1 gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of LDAF1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of LDAF1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with LDAF1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
