{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The long noncoding RNA LDLRAD4‐AS1, an antisense transcript of LDLRAD4, is predominantly localized in the nucleus of colorectal cancer (CRC) cells. Upregulated in a majority of CRC specimens and cell lines, LDLRAD4‐AS1 is associated with poor patient prognosis. Functionally, LDLRAD4‐AS1 enhances CRC cell migration and invasion in vitro and promotes metastasis in vivo. Mechanistically, LDLRAD4‐AS1 destabilizes the mRNA of LDLRAD4, leading to its decreased expression. This downregulation of LDLRAD4 subsequently induces epithelial‐to‐mesenchymal transition (EMT) via the upregulation of the transcription factor Snail, thereby establishing a novel LDLRAD4‐AS1–LDLRAD4–Snail regulatory axis that contributes to CRC progression and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shaobo Mo, Long Zhang, Weixing Dai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antisense lncRNA LDLRAD4-AS1 promotes metastasis by decreasing the expression of LDLRAD4 and predicts a poor prognosis in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-2338-y"}], "href": "https://doi.org/10.1038/s41419-020-2338-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32111819"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32111819"}]}]}]}