{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LEF1‐AS1 is a long noncoding RNA encoded in the lymphoid enhancer‐binding factor 1 (LEF1) locus that exhibits highly context‐dependent roles in human disease. In several solid tumors and vascular disorders—including coronary artery atherosclerosis, lung cancer, glioma, osteosarcoma, hepatocellular carcinoma, colorectal cancer, retinoblastoma, non–small‐cell lung cancer, prostate cancer, and ovarian cancer—LEF1‐AS1 is frequently upregulated and contributes to enhanced cell proliferation, migration, invasion, metastasis, chemoresistance, and angiogenesis. In these settings, LEF1‐AS1 acts predominantly as a competing endogenous RNA by sponging specific microRNAs (for example, miR‐544a, miR‐489‐3p, miR‐10a‐5p, miR‐136‐5p, miR‐30‐5p, miR‐221, miR‐330‐5p, and miR‐1285‐3p) to control downstream effectors such as PTEN, FOXP1, HIGD1A, LEF1, FUT8, SOX9, GJA1, CD44 and others—thereby activating oncogenic pathways including Wnt/β‐catenin, AKT, Hippo and additional signaling cascades."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In contrast, studies in hematological malignancies such as myelodysplastic syndrome and other myeloid disorders have shown that LEF1‐AS1 is downregulated, with its exogenous expression leading to cell cycle arrest via upregulation of tumor suppressors (for example, p21 and p27) and modulation of metabolic regulators."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, LEF1‐AS1 regulates additional biological processes beyond oncogenesis. In dental pulp stem cells, for instance, LEF1‐AS1 promotes osteogenic differentiation by sponging miR‐24‐3p to modulate TGFBR1 expression, while in models of spinal cord injury its knockdown alleviates inflammation and apoptosis via the miR‐222‐5p/RAMP3 axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings underscore the versatile and context‐dependent regulatory functions of LEF1‐AS1, highlighting its potential as both a prognostic biomarker and a therapeutic target across a broad spectrum of diseases ranging from cancer to cardiovascular and neurologic disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "18"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lina Zhang, Changyong Zhou, Qiaoji Qin, et al. 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