{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LELP1 (late cornified envelope‐like proline‐rich 1) is emerging as an important molecular player in skin barrier homeostasis and atopic disorders. Studies have shown that LELP1 expression is significantly upregulated in lesional atopic dermatitis (AD) skin, suggesting its involvement in the altered cornified envelope protein profile associated with the disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, genetic investigations have identified a notable association between a LELP1 polymorphism (rs7534334) and elevated serum immunoglobulin E levels, early-onset disease, and increased severity of AD, indicating that LELP1 variants may serve as potential biomarkers for disease risk and progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "4"}]}, {"type": "t", "text": " In addition, comparative genomic analyses have demonstrated that, while many key cornified envelope proteins are conserved across mammals, LELP1 has undergone degeneration in certain cetacean lineages, underscoring the adaptive modifications of epidermal barrier components in response to distinct environmental pressures."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings suggest that LELP1 plays a dual role in contributing both to the structural integrity of the epidermal barrier and to the modulation of immune responses in atopic skin conditions. Further research into its molecular mechanisms may provide valuable insights for the development of novel therapeutic strategies in AD and related atopic disorders.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Magdalena Trzeciak, Monika Sakowicz-Burkiewicz, Martyna Wesserling, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Association of a chromosome 1q21 locus in close proximity to a late cornified envelope-like proline-rich 1 (LELP1) gene with total serum IgE levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10038-007-0118-5"}], "href": "https://doi.org/10.1007/s10038-007-0118-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17387579"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17387579"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Magdalena Trzeciak, Martyna Wesserling, Tomasz Bandurski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of a Single Nucleotide Polymorphism in a Late Cornified Envelope-like Proline-rich 1 Gene (LELP1) with Atopic Dermatitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Derm Venereol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2340/00015555-2301"}], "href": "https://doi.org/10.2340/00015555-2301"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26608070"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26608070"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Roohi Rasool, Tabasum Shafi, Imtiyaz A Bhat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of epidermal differentiation complex (EDC) genetic variants with House Dust Mite sensitization in Atopic Dermatitis Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunobiology (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.imbio.2022.152214"}], "href": "https://doi.org/10.1016/j.imbio.2022.152214"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35452922"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35452922"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Karin Brigit Holthaus, Julia Lachner, Bettina Ebner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene duplications and gene loss in the epidermal differentiation complex during the evolutionary land-to-water transition of cetaceans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-91863-3"}], "href": "https://doi.org/10.1038/s41598-021-91863-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34112911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34112911"}]}]}]}