{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent multi‐omics and functional studies in ovarian cancer have uncovered an important tumor‐suppressive role for the long noncoding RNA LEMD1‐AS1. LEMD1‐AS1 is significantly downregulated in ovarian cancer tissues and cell lines compared with normal controls. Functional assays revealed that forced overexpression of LEMD1‐AS1 inhibited ovarian cancer cell proliferation, migration, and invasion in vitro and reduced tumor growth in vivo. Mechanistic investigations showed that LEMD1‐AS1 is predominantly localized in the cytoplasm, where it acts as a competing endogenous RNA by binding miR‑183‑5p; this interaction relieves miR‑183‑5p–mediated repression of TP53, thereby enhancing p53 expression and its associated tumor‐suppressive effects."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Furthermore, integrative analyses based on copy number variation and other genomic features have identified LEMD1‐AS1 as a potential prognostic biomarker for ovarian cancer, underscoring its clinical relevance in predicting patient survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ruowen Guo, Yide Qin "}, {"type": "b", "children": [{"type": "t", "text": "LEMD1-AS1 Suppresses Ovarian Cancer Progression Through Regulating miR-183-5p/TP53 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S250850"}], "href": "https://doi.org/10.2147/OTT.S250850"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32801762"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32801762"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mingjun Zheng, Yuexin Hu, Rui Gou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification three LncRNA prognostic signature of ovarian cancer based on genome-wide copy number variation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2019.109810"}], "href": "https://doi.org/10.1016/j.biopha.2019.109810"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32000042"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32000042"}]}]}]}