LGALS3BP Gene

HGNC Family	BTB (POZ) domain containing (BTBD), Endogenous ligands
Name	lectin, galactoside-binding, soluble, 3 binding protein
Description	The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LGALS3BP (also known as 90K or Mac‐2 binding protein) is a multifunctional, heavily glycosylated secreted glycoprotein that plays diverse roles in cancer progression, immune modulation, and fibrotic diseases. Elevated LGALS3BP expression in tumors has been associated with poor prognosis and enhanced metastatic potential, likely by modulating cell–cell and cell–matrix adhesion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, LGALS3BP is frequently enriched in tumor‐derived exosomes, suggesting that its incorporation into extracellular vesicles may facilitate intercellular communication that promotes tumor invasiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n LGALS3BP can also bind sialic acid–dependent immunomodulatory receptors (for example, Siglec‑9, as well as Siglec‑5 and Siglec‑10), thereby exerting immunoinhibitory functions that may allow tumor cells to evade immune surveillance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, secreted LGALS3BP from cancer cells interacts with galectin‑3 expressed on stromal cells, which stimulates these cells to produce interleukin‑6 and creates a tumor‑promoting inflammatory microenvironment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Clinically, specific glycoforms of LGALS3BP—such as the Mac‑2 binding protein glycan isomer (M2BPGi)—serve as surrogate markers for hepatic stellate cell activation and liver fibrosis, and elevated levels have been linked to adverse outcomes in chronic liver diseases and hepatocellular carcinoma."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "10"}]}, {"type": "t", "text": " Furthermore, LGALS3BP has been shown to interact with viral vectors such as recombinant adeno‑associated virus serotype 6, influencing vector aggregation and transduction efficiency."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, LGALS3BP exerts pleiotropic functions by fostering tumor cell adhesion and metastasis, modulating immune responses to favor tumor immune evasion, and serving as a clinically useful biomarker for fibrotic liver disease and cancer progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "11"}]}, {"type": "t", "text": " \n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Antonino Grassadonia, Nicola Tinari, Ida Iurisci, et al. "}, {"type": "b", "children": [{"type": "t", "text": "90K (Mac-2 BP) and galectins in tumor progression and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Glycoconj J (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1023/B:GLYC.0000014085.00706.d4"}], "href": "https://doi.org/10.1023/B:GLYC.0000014085.00706.d4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14758079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14758079"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Emily Capone, Stefano Iacobelli, Gianluca Sala "}, {"type": "b", "children": [{"type": "t", "text": "Role of galectin 3 binding protein in cancer progression: a potential novel therapeutic target."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-021-03085-w"}], "href": "https://doi.org/10.1186/s12967-021-03085-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34565385"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34565385"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Cristina Escrevente, Nicolas Grammel, Sebastian Kandzia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sialoglycoproteins and N-glycans from secreted exosomes of ovarian carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0078631"}], "href": "https://doi.org/10.1371/journal.pone.0078631"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24302979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24302979"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Heinz Läubli, Frederico Alisson-Silva, Michal A Stanczak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.593129"}], "href": "https://doi.org/10.1074/jbc.M114.593129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25320078"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25320078"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Elise P DeRoo, Shirley K Wrobleski, Evelyn M Shea, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of galectin-3 and galectin-3-binding protein in venous thrombosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2014-04-569939"}], "href": "https://doi.org/10.1182/blood-2014-04-569939"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25428218"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25428218"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ayaka M Silverman, Rie Nakata, Hiroyuki Shimada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A galectin-3-dependent pathway upregulates interleukin-6 in the microenvironment of human neuroblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-11-2165"}], "href": "https://doi.org/10.1158/0008-5472.CAN-11-2165"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22389450"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22389450"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yasushi Fukaya, Hiroyuki Shimada, Ling-Chi Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of galectin-3-binding protein as a factor secreted by tumor cells that stimulates interleukin-6 expression in the bone marrow stroma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M803115200"}], "href": "https://doi.org/10.1074/jbc.M803115200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18450743"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18450743"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ken Shirabe, Yuki Bekki, Dolgormaa Gantumur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mac-2 binding protein glycan isomer (M2BPGi) is a new serum biomarker for assessing liver fibrosis: more than a biomarker of liver fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gastroenterol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00535-017-1425-z"}], "href": "https://doi.org/10.1007/s00535-017-1425-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29318378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29318378"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Rui Chen, Yexiong Tan, Min Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Development of glycoprotein capture-based label-free method for the high-throughput screening of differential glycoproteins in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Proteomics (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/mcp.M110.006445"}], "href": "https://doi.org/10.1074/mcp.M110.006445"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21474793"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21474793"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yoshihiro Kamada, Hideki Fujii, Hironobu Fujii, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum Mac-2 binding protein levels as a novel diagnostic biomarker for prediction of disease severity and nonalcoholic steatohepatitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proteomics Clin Appl (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/prca.201200137"}], "href": "https://doi.org/10.1002/prca.201200137"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23775887"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23775887"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jerome Denard, Cyriaque Beley, Robert Kotin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human galectin 3 binding protein interacts with recombinant adeno-associated virus type 6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00297-12"}], "href": "https://doi.org/10.1128/JVI.00297-12"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22496229"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22496229"}]}]}]}
Synonyms	BTBD17B, GP90, M2BP, CYCAP, TANGO10B, 90K, MAC-2-BP
Proteins	LG3BP_HUMAN
NCBI Gene ID	3959
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

LGALS3BP has 16,169 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 117 datasets.

Click the + buttons to view associations for LGALS3BP from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

LGALS3BP Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LGALS3BP gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of LGALS3BP gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of LGALS3BP gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of LGALS3BP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of LGALS3BP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LGALS3BP gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of LGALS3BP gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of LGALS3BP gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of LGALS3BP gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of LGALS3BP gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of LGALS3BP gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of LGALS3BP gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with LGALS3BP protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with LGALS3BP gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LGALS3BP gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of LGALS3BP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of LGALS3BP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of LGALS3BP gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of LGALS3BP gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing LGALS3BP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing LGALS3BP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing LGALS3BP protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with LGALS3BP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with LGALS3BP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of LGALS3BP gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with LGALS3BP gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with LGALS3BP gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with LGALS3BP gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of LGALS3BP protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by LGALS3BP gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with LGALS3BP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with LGALS3BP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with LGALS3BP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with LGALS3BP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at LGALS3BP gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LGALS3BP gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of LGALS3BP gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing LGALS3BP from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with LGALS3BP gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of LGALS3BP gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.