{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies underscore the critical roles played by long non‐coding RNAs (lncRNAs) in diverse human diseases. While dysregulated lncRNAs have been implicated in the development and progression of conditions such as atherosclerosis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "and glioblastoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", only one study has directly addressed the function of LGALS8‑AS1. In breast cancer, LGALS8‑AS1 is markedly overexpressed and correlates with poor survival outcomes. Functioning as an oncogenic lncRNA, LGALS8‑AS1 facilitates metastatic progression by promoting cell migration and invasion. Mechanistically, it operates via a reciprocal regulatory loop with miR‑125b‑5p and SOX12, a signaling axis that disrupts normal cellular checks and propels the metastatic process. These findings not only elucidate the role of LGALS8‑AS1 in breast cancer metastasis but also indicate that targeting the LGALS8‑AS1/miR‑125b‑5p/SOX12 pathway could provide a promising therapeutic strategy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chuan-Hui Wang, Hui-Hua Shi, Lin-Hui Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Key lncRNAs Associated With Atherosclerosis Progression Based on Public Datasets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2019.00123"}], "href": "https://doi.org/10.3389/fgene.2019.00123"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30873207"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30873207"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhenyu Gong, Fan Hong, Hongxiang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An eight-mRNA signature outperforms the lncRNA-based signature in predicting prognosis of patients with glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12881-020-0992-7"}], "href": "https://doi.org/10.1186/s12881-020-0992-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32188434"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32188434"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Duanyang Zhai, Tianfu Li, Runyi Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LGALS8-AS1 Promotes Breast Cancer Metastasis Through miR-125b-5p/SOX12 Feedback Regulatory Network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2021.711684"}], "href": "https://doi.org/10.3389/fonc.2021.711684"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34745940"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34745940"}]}]}]}