LGALS9B Gene

HGNC Family	Lectins, galactoside-binding (LGALS)
Name	lectin, galactoside-binding, soluble, 9B
Description	This gene was initially thought to represent a pseudogene of galectin 9; however, this transcript has good exon-intron structure and encodes a predicted protein of the same size as and highly similar to galectin 9. This gene is one of two similar loci on chromosome 17p similar to galectin 9 and now thought to be protein-encoding. This gene is the more centromeric gene. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LGALS9B appears to play multifaceted roles in cancer biology by influencing apoptosis, immune regulation, and tumor progression. The protein encoded by this gene is related to galectin‐9, a lectin that has been shown to induce apoptosis in thymocytes and other immune cells, thereby modulating acquired immunity and contributing to anti‐cancer effects."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, alterations in the methylation status of LGALS9B have been linked to patient prognosis. For instance, in kidney renal papillary cell carcinoma, epigenetic modifications affecting LGALS9B were among the key biomarkers that stratified patients into distinct survival risk groups, underscoring its potential utility as a prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, network analyses in hepatocellular carcinoma have identified LGALS9B as an interacting partner of PDZ-binding kinase, suggesting that it may integrate into broader signaling cascades that drive tumor progression and modulate the tumor immune microenvironment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Together, these findings indicate that LGALS9B is involved in the regulation of apoptosis and immune responses and holds promise both as a prognostic marker and as a potential target for therapeutic intervention in various cancers.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Koji Fujita, Hisakazu Iwama, Kyoko Oura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cancer Therapy Due to Apoptosis: Galectin-9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms18010074"}], "href": "https://doi.org/10.3390/ijms18010074"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28045432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28045432"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ying-Lei Wang, Ying-Ying Zhang "}, {"type": "b", "children": [{"type": "t", "text": "cg04448376, cg24387542, cg08548498, and cg14621323 as a Novel Signature to Predict Prognosis in Kidney Renal Papillary Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/4854390"}], "href": "https://doi.org/10.1155/2020/4854390"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33381555"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33381555"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wei Mu, Yaoli Xie, Jinhu Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High expression of PDZ-binding kinase is correlated with poor prognosis and immune infiltrates in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Surg Oncol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12957-021-02479-w"}], "href": "https://doi.org/10.1186/s12957-021-02479-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35065633"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35065633"}]}]}]}
Proteins	LEG9B_HUMAN
NCBI Gene ID	284194
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

LGALS9B has 1,747 functional associations with biological entities spanning 7 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 48 datasets.

Click the + buttons to view associations for LGALS9B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

LGALS9B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LGALS9B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of LGALS9B gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LGALS9B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of LGALS9B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LGALS9B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of LGALS9B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of LGALS9B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of LGALS9B gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of LGALS9B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with LGALS9B gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with LGALS9B gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by LGALS9B gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with LGALS9B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at LGALS9B gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LGALS9B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of LGALS9B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of LGALS9B gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of LGALS9B gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of LGALS9B gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Viral Infections	virus perturbations changing expression of LGALS9B gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
	GO Biological Process Annotations 2023	biological processes involving LGALS9B gene from the curated GO Biological Process Annotations 2023 dataset.
	GO Cellular Component Annotations 2023	cellular components containing LGALS9B protein from the curated GO Cellular Component Annotations 2023 dataset.
	GO Molecular Function Annotations 2015	molecular functions performed by LGALS9B gene from the curated GO Molecular Function Annotations 2015 dataset.
	GTEx Tissue Gene Expression Profiles	tissues with high or low expression of LGALS9B gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
	GTEx Tissue Gene Expression Profiles 2023	tissues with high or low expression of LGALS9B gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
	GTEx Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of LGALS9B gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
	HPA Cell Line Gene Expression Profiles	cell lines with high or low expression of LGALS9B gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
	HPA Tissue Gene Expression Profiles	tissues with high or low expression of LGALS9B gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
	HPA Tissue Protein Expression Profiles	tissues with high or low expression of LGALS9B protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
	HPA Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of LGALS9B gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
	HPM Cell Type and Tissue Protein Expression Profiles	cell types and tissues with high or low expression of LGALS9B protein relative to other cell types and tissues from the HPM Cell Type and Tissue Protein Expression Profiles dataset.
	InterPro Predicted Protein Domain Annotations	protein domains predicted for LGALS9B protein from the InterPro Predicted Protein Domain Annotations dataset.
	JASPAR Predicted Transcription Factor Targets	transcription factors regulating expression of LGALS9B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	cell lines with high or low copy number of LGALS9B gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	transcription factor perturbations changing expression of LGALS9B gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
	LOCATE Predicted Protein Localization Annotations	cellular components predicted to contain LGALS9B protein from the LOCATE Predicted Protein Localization Annotations dataset.
	MiRTarBase microRNA Targets	microRNAs targeting LGALS9B gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.
	MotifMap Predicted Transcription Factor Targets	transcription factors regulating expression of LGALS9B gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
	MPO Gene-Phenotype Associations	phenotypes of transgenic mice caused by LGALS9B gene mutations from the MPO Gene-Phenotype Associations dataset.
	NURSA Protein Complexes	protein complexs containing LGALS9B protein recovered by IP-MS from the NURSA Protein Complexes dataset.
	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of LGALS9B gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	PFOCR Pathway Figure Associations 2023	pathways involving LGALS9B protein from the PFOCR Pathway Figure Associations 2023 dataset.
	PFOCR Pathway Figure Associations 2024	pathways involving LGALS9B protein from the Wikipathways PFOCR 2024 dataset.
	Rummagene Transcription Factor Associations 2026	transcription factors regulating expression of LGALS9B gene from the Rummagene Transcription Factor Associations 2026 dataset.
	TargetScan Predicted Nonconserved microRNA Targets	microRNAs regulating expression of LGALS9B gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
	TCGA Signatures of Differentially Expressed Genes for Tumors	tissue samples with high or low expression of LGALS9B gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
	TISSUES Curated Tissue Protein Expression Evidence Scores	tissues with high expression of LGALS9B protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.
	TISSUES Experimental Tissue Protein Expression Evidence Scores	tissues with high expression of LGALS9B protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.