{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA LHFPL3‐AS1 exerts oncogenic functions in multiple cancer types through distinct molecular mechanisms. In melanoma stem cells, for example, an alternatively spliced isoform—LHFPL3‐AS1–long—is generated via PTBP1‐mediated processing and acts as a competing endogenous RNA to sequester miR‑181a‑5p, thereby preventing miRNA‐mediated degradation of BCL2 mRNA and inhibiting apoptosis, which ultimately contributes to tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In nasopharyngeal carcinoma, LHFPL3‐AS1 has been implicated in cancer progression by modulating the miR‑143‑5p/homeobox A6 (HOXA6) signaling axis, thereby affecting cellular proliferation, migration, and resistance to radiation therapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, in uveal melanoma, elevated LHFPL3‐AS1 expression has been incorporated into prognostic prediction models associated with an inflammatory tumor microenvironment and metastatic risk."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In oral squamous cell carcinoma, upregulation of LHFPL3‐AS1 promotes malignant behaviors—including enhanced cell proliferation, migration, invasion, and chemotherapy resistance—by acting as a competing endogenous RNA for miR‑194‑5p to increase CHSY1 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Overall, these findings underscore the multifaceted role of LHFPL3‐AS1 in tumor progression via regulation of apoptosis, cell proliferation, and drug resistance, and highlight its potential as a promising therapeutic target in various cancer settings.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Song Zhang, Haitao Wan, Xiaobo Zhang "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LHFPL3-AS1 contributes to tumorigenesis of melanoma stem cells via the miR-181a-5p/BCL2 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-03141-1"}], "href": "https://doi.org/10.1038/s41419-020-03141-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33149126"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33149126"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Qian Peng, Linbo Liu, Hui Pei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A LHFPL3-AS1/miR-580-3p/STAT3 Feedback Loop Promotes the Malignancy in Melanoma via Activation of JAK2/STAT3 Signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-19-1046"}], "href": "https://doi.org/10.1158/1541-7786.MCR-19-1046"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32753471"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32753471"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Weifeng Wang, Zhuo Zhang, Yundong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulated long non-coding RNA LHFPL3 antisense RNA 1 inhibits the radiotherapy resistance of nasopharyngeal carcinoma via modulating microRNA-143-5p/homeobox A6 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2024386"}], "href": "https://doi.org/10.1080/21655979.2021.2024386"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35176945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35176945"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wenchuan Zhou, Jing Li "}, {"type": "b", "children": [{"type": "t", "text": "Integrated Analysis of Genes Associated With Immune Microenvironment and Distant Metastasis in Uveal Melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cell Dev Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcell.2022.874839"}], "href": "https://doi.org/10.3389/fcell.2022.874839"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35433689"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35433689"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jiandong Li, Xiaohu Xu, Dandan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LHFPL3-AS1 Promotes Oral Squamous Cell Carcinoma Growth and Cisplatin Resistance Through Targeting miR-362-5p/CHSY1 Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S298679"}], "href": "https://doi.org/10.2147/OTT.S298679"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33833527"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33833527"}]}]}]}