{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Although the collected abstracts describe a broad spectrum of roles for non‐coding RNAs – ranging from the regulation of interchromosomal interactions in T‐cell differentiation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", to rapid transcriptome reprogramming in response to estrogen"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "and to modulation of tumor phenotypes in gynecologic cancers"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", none of these studies provide a direct analysis of LHX4‐AS1, a long noncoding RNA transcribed antisense to the LIM homeobox gene LHX4. By analogy to other antisense lncRNAs that have been shown to regulate the expression of nearby protein‐coding genes through mechanisms including transcriptional interference, RNA stabilization, and epigenetic remodeling, LHX4‐AS1 may be postulated to act as a modulator of LHX4 expression. Its function might therefore influence developmental programs or disease processes in which LHX4 is implicated. However, in the absence of data directly addressing LHX4‐AS1 in these reports, its precise biological role remains to be established. Further targeted studies will be needed to determine whether LHX4‐AS1 coordinates the expression of LHX4 – or other genes – and to delineate its contribution to cellular physiology and pathology.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lark Kyun Kim, Enric Esplugues, Cornelia E Zorca, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oct-1 regulates IL-17 expression by directing interchromosomal associations in conjunction with CTCF in T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2014.02.004"}], "href": "https://doi.org/10.1016/j.molcel.2014.02.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24613343"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24613343"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Nasun Hah, Charles G Danko, Leighton Core, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A rapid, extensive, and transient transcriptional response to estrogen signaling in breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2011.03.042"}], "href": "https://doi.org/10.1016/j.cell.2011.03.042"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21549415"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21549415"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Rozita Akrami, Anders Jacobsen, Jessica Hoell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive analysis of long non-coding RNAs in ovarian cancer reveals global patterns and targeted DNA amplification."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0080306"}], "href": "https://doi.org/10.1371/journal.pone.0080306"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24265805"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24265805"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Maria A Smolle, Marc D Bullock, Hui Ling, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Non-Coding RNAs in Endometrial Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms161125962"}], "href": "https://doi.org/10.3390/ijms161125962"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26556343"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26556343"}]}]}]}