{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Multiple studies have demonstrated that long non‐coding RNAs (lncRNAs) play key roles in tumor biology across various cancer types. In non‐small cell lung cancer (NSCLC), the lncRNA LIMD1 antisense RNA 1 (LIMD1‐AS1) has emerged as a critical tumor suppressor. Specifically, in NSCLC samples and cell lines, LIMD1‐AS1 is downregulated, and its experimental knockdown leads to enhanced tumor growth both in vitro and in vivo. Mechanistic investigations revealed that LIMD1‐AS1 exerts its function by interacting with the RNA‐binding protein heterogeneous nuclear ribonucleoprotein U (hnRNP U), which in turn stabilizes LIMD1 mRNA. This stabilization enhances LIMD1 expression—a known tumor suppressor in lung cancer—thereby inhibiting cell proliferation and promoting apoptosis (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, analogous evidence from studies in other malignancies supports the broader oncological promise of lncRNA-mediated regulation. In clear cell renal cell carcinoma, genome-wide analyses have identified distinct copy number alterations that impact tumor progression, while in melanoma, comprehensive ceRNA network analyses have underscored the prognostic potential of lncRNAs (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Together, these findings highlight that LIMD1‐AS1 not only reinforces LIMD1’s tumor suppressive activity in NSCLC but also exemplifies a broader mechanism wherein lncRNAs modulate gene stability and function, offering promising targets for future molecular‐targeted therapies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jianyuan Pan, Yongqin Tang, Shumei Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LIMD1-AS1 suppressed non-small cell lung cancer progression through stabilizing LIMD1 mRNA via hnRNP U."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.2898"}], "href": "https://doi.org/10.1002/cam4.2898"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32239804"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32239804"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ling Wang, Ayrianna Sparks-Wallace, Jared L Casteel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Algorithm-Based Meta-Analysis Reveals the Mechanistic Interaction of the Tumor Suppressor LIMD1 With Non-Small-Cell Lung Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2021.632638"}], "href": "https://doi.org/10.3389/fonc.2021.632638"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33869018"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33869018"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "H-J Thiesen, F Steinbeck, M Maruschke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stratification of clear cell renal cell carcinoma (ccRCC) genomes by gene-directed copy number alteration (CNA) analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0176659"}], "href": "https://doi.org/10.1371/journal.pone.0176659"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28486536"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28486536"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Nian Liu, Zijian Liu, Xinxin Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive Analysis of a Competing Endogenous RNA Network Identifies Seven-lncRNA Signature as a Prognostic Biomarker for Melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2019.00935"}], "href": "https://doi.org/10.3389/fonc.2019.00935"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31649871"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31649871"}]}]}]}