{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long intergenic non‐coding RNA, linc‐ROR, functions as a key regulator in both the maintenance of pluripotency in human embryonic stem cells (ESCs) and the progression of cancer. In ESCs, linc‐ROR acts as a competing endogenous RNA (ceRNA) that shares microRNA‐response elements with core transcription factors—such as OCT4, SOX2, and NANOG—thereby protecting these pivotal factors from microRNA‐mediated suppression and establishing a feedback loop that underlies self‐renewal and proper differentiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n In breast cancer, linc‐ROR is upregulated and its ectopic overexpression in mammary epithelial cells induces an epithelial‐to‐mesenchymal transition (EMT) program. This linc‐ROR‐mediated ceRNA activity sequesters microRNAs like miR-205, preventing the degradation of targets such as ZEB2, an EMT inducer, consequently enhancing cell migration, invasion, and the acquisition of stem cell characteristics that contribute to tumor progression and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yue Wang, Zhenyu Xu, Junfeng Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human embryonic stem cell self-renewal."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2013.03.002"}], "href": "https://doi.org/10.1016/j.devcel.2013.03.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23541921"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23541921"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "P Hou, Y Zhao, Z Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2014.249"}], "href": "https://doi.org/10.1038/cddis.2014.249"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24922071"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24922071"}]}]}]}