{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00028 is a long intergenic non‐coding RNA that has emerged as a regulatory player in diverse disease contexts. In osteosarcoma, LINC00028 was identified as part of a competing endogenous RNA network regulating key mRNAs (RAP1B, ATF2, and PPM1B) via interactions with miRNAs (hsa‐miR‑124 and hsa‑miR‑7). In this setting, increased expression of LINC00028 was associated with improved patient prognosis and appears to modulate the MAPK signaling pathway, suggesting it may have a protective role against tumor recurrence."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In an independent study focusing on glaucoma, LINC00028 expression was significantly elevated in both patient tissues and transforming growth factor β1 (TGFβ1)–treated human tenon capsule fibroblasts. Functional assays revealed that downregulation of LINC00028 curtailed TGFβ1-induced fibroblast proliferation, migration, invasion, epithelial-mesenchymal transition, fibrosis, and autophagy. Mechanistically, LINC00028 acted as a competitive endogenous RNA that sequestered miR‑204‑5p, thereby promoting these cellular processes and contributing to the formation of post-surgical scarring."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings indicate that LINC00028 plays context-dependent roles by modulating key signaling pathways—exerting a potentially beneficial effect in osteosarcoma through its association with improved prognosis, while facilitating fibrotic responses in glaucoma. This multifaceted regulatory capacity highlights its promise as both a prognostic biomarker and a therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shanyong Zhang, Lei Ding, Xin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of biomarkers associated with the recurrence of osteosarcoma using ceRNA regulatory network analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2019.4108"}], "href": "https://doi.org/10.3892/ijmm.2019.4108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30816442"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30816442"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Huali Sui, Shanshan Fan, Wenjing Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00028 regulates the development of TGFβ1-treated human tenon capsule fibroblasts by targeting miR-204-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2020.01.096"}], "href": "https://doi.org/10.1016/j.bbrc.2020.01.096"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32085895"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32085895"}]}]}]}