{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00051 (alternatively annotated as NCRNA00051) is a long non‐coding RNA that has emerged from genome‐wide studies as a potential contributor to disease susceptibility. In a recent genome‐wide association study focused on sporadic Parkinson’s disease in a Han Chinese cohort, the FLJ43860/NCRNA00051 locus (represented by the variant kgp4105983) showed one of the strongest associations with disease risk. Although its precise molecular function is not yet fully characterized, this finding suggests that LINC00051 may participate in regulatory networks affecting neuronal processes—potentially influencing pathways such as axon guidance, extracellular matrix–receptor interactions, and synaptic communication—that are critical for neuronal integrity and function. Understanding its role in these pathways may offer insights into the molecular mechanisms underpinning neurodegeneration in Parkinson’s disease. Further research is needed to elucidate its exact function as well as its potential involvement in the broader regulatory landscapes observed in other conditions, including alcohol‐related organ damage, breast cancer regulatory networks, and epilepsy, where non‐coding RNAs play key modulatory roles."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sathish Kumar Natarajan, Joseph M Pachunka, Justin L Mott "}, {"type": "b", "children": [{"type": "t", "text": "Role of microRNAs in Alcohol-Induced Multi-Organ Injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomolecules (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/biom5043309"}], "href": "https://doi.org/10.3390/biom5043309"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26610589"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26610589"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuhan Zhang, Yongfeng Li, Qing Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of an lncRNA‑miRNA‑mRNA interaction mechanism in breast cancer based on bioinformatic analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2017.7304"}], "href": "https://doi.org/10.3892/mmr.2017.7304"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28849135"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28849135"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Eduardo Pérez-Palma, Ingo Helbig, Karl Martin Klein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heterogeneous contribution of microdeletions in the development of common generalised and focal epilepsies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmedgenet-2016-104495"}], "href": "https://doi.org/10.1136/jmedgenet-2016-104495"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28756411"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28756411"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yakun Hu, Libing Deng, Jie Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Pooling Genome-Wide Association Study Combining a Pathway Analysis for Typical Sporadic Parkinson's Disease in the Han Population of Chinese Mainland."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Neurobiol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12035-015-9331-y"}], "href": "https://doi.org/10.1007/s12035-015-9331-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26227905"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26227905"}]}]}]}