{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00092 is a long noncoding RNA that plays diverse, context‐dependent roles in cancer and fibrotic diseases. In epithelial ovarian cancer, LINC00092 functions as a key mediator of metastatic progression by driving interactions between tumor cells and cancer‐associated fibroblasts, thereby promoting peritoneal dissemination."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In breast invasive ductal carcinoma, LINC00092 is downregulated and its overexpression suppresses tumor cell proliferation, colony formation, migration, and invasion via modulation of the miR‐1827/SFRP1 axis, suggesting a tumor suppressor function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in lung adenocarcinoma, reduced expression of LINC00092 is associated with advanced pathological stage and poor overall survival, with potential involvement in NF-κB, HIF-1, and ErbB signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In the setting of cardiac fibrosis, LINC00092 attenuates cardiac fibroblast activation by suppressing glycolysis and inhibiting ERK signaling, highlighting its role in metabolic reprogramming."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Beyond these functions, LINC00092 has emerged as a potential diagnostic biomarker in colon adenocarcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "and as a component of prognostic signatures in small-cell lung cancer and breast cancer where its altered expression correlates with patient outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Collectively, these studies indicate that LINC00092 is an important regulator of tumor progression, metastasis, and cellular metabolism, with potential utility as a biomarker and therapeutic target across multiple disease contexts.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Linjie Zhao, Gaili Ji, Xiaobing Le, et al. 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