{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00106 has emerged as a potential tumor‐suppressive long noncoding RNA with roles in multiple cancer types. In thyroid cancer, LINC00106 is significantly downregulated in tumor tissues relative to normal tissues, and its reduced expression correlates with advanced tumor stage, lymphatic metastasis, and poorer overall survival. Functional studies have shown that silencing LINC00106 in thyroid cancer cell lines enhances migratory and invasive capabilities and promotes epithelial–mesenchymal transition (EMT), suggesting that LINC00106 normally acts to restrain these malignant properties."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of gastric cancer, LINC00106 has been identified as one of several autophagy‐related long noncoding RNAs incorporated into prognostic risk signatures. Analyses of gene expression data reveal that its inclusion in these multi‐lncRNA panels is associated with the ability to stratify patients into high‐ and low‐risk groups for overall survival. Moreover, when analyzed within a competing endogenous RNA (ceRNA) network, LINC00106—as well as other lncRNAs—demonstrates potential as a prognostic biomarker and a candidate therapeutic target for gastric cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although another study has focused on pseudoautosomal region genes in hematological malignancies, it does not directly address LINC00106. Nonetheless, the recurrent identification of LINC00106 across diverse malignant settings underscores its emerging relevance. Collectively, these findings support a role for LINC00106 as a tumor suppressor that hinders processes such as EMT in thyroid cancer and as a valuable component of prognostic signatures in gastric cancer, warranting further investigation into its molecular mechanisms and potential clinical applications."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "X-J Wang, H-T Zheng, J Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00106 prevents against metastasis of thyroid cancer by inhibiting epithelial-mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202010_23215"}], "href": "https://doi.org/10.26355/eurrev_202010_23215"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33090406"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33090406"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wenwen Wang, Qingshan Pei, Lifen Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction of a Prognostic Signature of 10 Autophagy-Related lncRNAs in Gastric Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Gen Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/IJGM.S348943"}], "href": "https://doi.org/10.2147/IJGM.S348943"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35411177"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35411177"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mingran Qi, Bingxin Yu, Huiyuan Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated analysis of a ceRNA network reveals potential prognostic lncRNAs in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.2760"}], "href": "https://doi.org/10.1002/cam4.2760"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31923354"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31923354"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Stephanie Weng, Samuel A Stoner, Dong-Er Zhang "}, {"type": "b", "children": [{"type": "t", "text": "Sex chromosome loss and the pseudoautosomal region genes in hematological malignancies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.12050"}], "href": "https://doi.org/10.18632/oncotarget.12050"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27655702"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27655702"}]}]}]}