{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNAs (lncRNAs) have emerged as key regulators in cancer biology, and recent integrative analyses of competing endogenous RNA (ceRNA) networks in gastric cancer have identified LINC00111 as a promising prognostic biomarker specifically in Helicobacter pylori–positive cases (5). In this context, differential expression profiling of gastric adenocarcinoma samples revealed that LINC00111, along with other lncRNAs and mRNAs, is significantly associated with several cancer‐related pathways—including cytokine–cytokine receptor interaction, HIF‐1, and Wnt signaling—that contribute to tumor progression and modulate the immune response in the setting of H. pylori infection (5). Although previous studies have elucidated novel platelet proteins involved in thrombosis (1), characterized post‐translational epigenetic regulators (2), identified new susceptibility loci and noncoding RNAs in basal cell carcinoma (3), and investigated factors governing ciliogenesis and related human diseases (4), these investigations did not address the role of LINC00111. By contrast, the study focused on H. pylori–positive gastric cancer demonstrates that LINC00111 may function as a key component of the ceRNA network, potentially influencing gene regulatory circuits that underpin tumor biology in this subset of patients (5). Collectively, these findings highlight the potential utility of LINC00111 as a biomarker for prognosis and underscore its relevance in the molecular pathogenesis of H. pylori–related gastric cancer."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Marie N O'Connor, Isabelle I Salles, Ana Cvejic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2008-06-162693"}], "href": "https://doi.org/10.1182/blood-2008-06-162693"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19109564"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19109564"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Obiamaka Obianyo, Corey P Causey, Tanesha C Osborne, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Chembiochem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cbic.201000209"}], "href": "https://doi.org/10.1002/cbic.201000209"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20480486"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20480486"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Harvind S Chahal, Wenting Wu, Katherine J Ransohoff, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms12510"}], "href": "https://doi.org/10.1038/ncomms12510"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27539887"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27539887"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Gabrielle Wheway, Miriam Schmidts, Dorus A Mans, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb3201"}], "href": "https://doi.org/10.1038/ncb3201"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26167768"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26167768"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yanyan Liu, Jingyu Zhu, Xiaoli Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ceRNA network construction and comparison of gastric cancer with or without Helicobacter pylori infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.27467"}], "href": "https://doi.org/10.1002/jcp.27467"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30370523"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30370523"}]}]}]}