| Name | long intergenic non-protein coding RNA 113 |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent transcriptomic analyses have identified long non‐coding RNAs with potential roles in a variety of human diseases. In studies of macrophage responses to Mycobacterium tuberculosis infection and lung adenocarcinoma (LAD), one such lncRNA—LINC00113—was evaluated as part of broader panels of non‐coding transcripts. In the investigation focused on tuberculosis, a comprehensive RNA‐Seq approach profiling both mRNAs and ncRNAs revealed distinct expression patterns in different macrophage types upon infection, although LINC00113 was not specifically highlighted for its function in this context."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, a separate study examining lncRNA expression in LAD demonstrated that LINC00113 is among several lncRNAs whose expression levels are significantly altered between tumor and adjacent non-tumor lung tissues—and further between LAD cases with and without lymphatic metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " The differential expression of LINC00113 in LAD suggests that it may play a role in tumor pathogenesis and could serve as a potential indicator for diagnosis or therapeutic targeting. Collectively, these studies underscore the importance of profiling lncRNAs like LINC00113 to better understand their contributions to infectious and oncologic disease processes.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Audrey C Papp, Abul K Azad, Maciej Pietrzak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AmpliSeq transcriptome analysis of human alveolar and monocyte-derived macrophages over time in response to Mycobacterium tuberculosis infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0198221"}], "href": "https://doi.org/10.1371/journal.pone.0198221"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29847580"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29847580"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhiyi Yang, Hongli Li, Zhaoyan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Microarray expression profile of long non-coding RNAs in human lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thorac Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1759-7714.12845"}], "href": "https://doi.org/10.1111/1759-7714.12845"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30151992"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30151992"}]}]}]}
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| Synonyms | NCRNA00113, C21ORF23 |
| NCBI Gene ID | 54088 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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LINC00113 has 429 functional associations with biological entities spanning 5 categories (molecular profile, organism, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 18 datasets.
Click the + buttons to view associations for LINC00113 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of LINC00113 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of LINC00113 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of LINC00113 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of LINC00113 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of LINC00113 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at LINC00113 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of LINC00113 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of LINC00113 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of LINC00113 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of LINC00113 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of LINC00113 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of LINC00113 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with LINC00113 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with LINC00113 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of LINC00113 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of LINC00113 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at LINC00113 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of LINC00113 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
