{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Multiple independent studies have demonstrated that the long non‐coding RNA LINC00114 plays diverse regulatory roles in human disease, particularly in various cancers. In colorectal cancer, LINC00114 is a component of a metastasis‐associated competing endogenous RNA network; its inhibition has been shown to enhance cell migration, invasion, and proliferation while directly interacting with miR‑135a, which supports its function as a tumor suppressor in controlling metastatic potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In nasopharyngeal carcinoma, LINC00114 is upregulated and promotes cell proliferation, migration, and radioresistance by targeting miR‑203 and modulating the ERK/JNK signaling pathway; its knockdown effectively reduces tumor growth and improves radiosensitivity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in esophageal cancer, LINC00114 is overexpressed and facilitates tumor development by recruiting EZH2 to mediate the trimethylation of H3K27 at the promoter region of the tumor suppressor gene DLC1, thereby promoting cell growth, migration, invasion, and enhanced glycolytic metabolism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In colon cancer, elevated levels of LINC00114 are associated with early tumor stages and poorer overall survival, suggesting its potential as an early diagnostic marker and prognostic indicator in this malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Beyond cancer, epigenome‐wide analyses have identified differential DNA methylation at the promoter region of LINC00114 in maternal blood that is significantly associated with spontaneous preterm birth, highlighting a potential role of LINC00114 as a biomarker in obstetric complications."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, transcriptome mapping of the human hippocampus has revealed an intrinsic over‐expression of LINC00114 compared to the whole brain, suggesting that it may contribute to region‑specific gene regulation in the central nervous system."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shuzhen Liu, Qing Cao, Guoyan An, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "LINC00114 promoted nasopharyngeal carcinoma progression and radioresistance in vitro and in vivo through regulating ERK/JNK signaling pathway via targeting miR-203."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202003_20517"}], "href": "https://doi.org/10.26355/eurrev_202003_20517"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32196600"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32196600"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jianzhang Qin, Yishuai Li, Zhe Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00114 stimulates growth and glycolysis of esophageal cancer cells by recruiting EZH2 to enhance H3K27me3 of DLC1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Epigenetics (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13148-022-01258-y"}], "href": "https://doi.org/10.1186/s13148-022-01258-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35414117"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35414117"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Gu Xi, Xu Ziyu, Liu Yiting, et al. 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