{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00115 is an oncogenic long non‐coding RNA that is frequently overexpressed in a variety of solid tumors. In several cancer types—including breast, lung, glioma, cervical, colorectal, ovarian, prostate, and retinoblastoma—it is associated with poor clinical outcomes by promoting malignant cellular behaviors such as proliferation, migration, invasion, and maintenance of stem‐like properties (1,2,3,4,5,6,7,8,9,10). Mechanistically, LINC00115 commonly acts as a competing endogenous RNA (ceRNA) by “sponging” tumor‐suppressive microRNAs, thereby releasing oncogenic targets. For instance, in triple‐negative breast cancer it sequesters miR‑7 to decrease the expression of KLF4 and promote metastasis (2); in lung cancer, LINC00115 binds to miR‑607 to regulate ITGB1 expression and also modulates epithelial‑mesenchymal transition markers, thereby enhancing invasion and migration (3,10). In glioma, its upregulation by TGF‑β enables LINC00115 to sponge the miR‑200 family and increase ZEB1 and ZNF596 levels, contributing to glioma stem‑like cell self‑renewal and tumor growth (4). Similarly, in colorectal and retinoblastoma settings, LINC00115 targets miR‑489‑3p to activate the PI3K/AKT/mTOR pathway or to upregulate PFKFB2, respectively, thereby sustaining tumor progression (6,9). In ovarian and prostate cancers, the ceRNA action of LINC00115—through interactions with miR‑30a and miR‑212‑5p, respectively—leads to upregulation of SOX9 or FZD5 and subsequent activation of the Wnt/β‑catenin pathway (7,8). Additionally, its dysregulated expression and incorporation into multi‑RNA prognostic signatures further highlight its potential as a diagnostic and prognostic biomarker in various malignancies (1,5).\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Overall, the available studies indicate that LINC00115 exerts its oncogenic effects by modulating key signaling pathways through miRNA sponging, making it a promising target for therapeutic intervention across multiple cancer types."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bin Jiang, Su Hailong, Jun Yuan, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC00115 promotes breast cancer metastasis by inhibiting miR-7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Open Bio (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/2211-5463.12842"}], "href": "https://doi.org/10.1002/2211-5463.12842"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32175684"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32175684"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Bin Wu, Xingkui Xue, Shaoming Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC00115 facilitates lung cancer progression through miR-607/ITGB1 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Environ Toxicol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/tox.23367"}], "href": "https://doi.org/10.1002/tox.23367"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34643030"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34643030"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jianming Tang, Bo Yu, Yanxin Li, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Identification of Long Noncoding RNA Expression Profiles in HPV-Negative Cervical Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gynecol Obstet Invest (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000510030"}], "href": "https://doi.org/10.1159/000510030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33053555"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33053555"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Weiyu Feng, Baodong Li, Jinbang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Non-coding RNA LINC00115 Contributes to the Progression of Colorectal Cancer by Targeting miR-489-3p via the PI3K/AKT/mTOR Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2020.567630"}], "href": "https://doi.org/10.3389/fgene.2020.567630"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33193658"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33193658"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Rui Hou, Luo Jiang "}, {"type": "b", "children": [{"type": "t", "text": "LINC00115 promotes stemness and inhibits apoptosis of ovarian cancer stem cells by upregulating SOX9 and inhibiting the Wnt/β-catenin pathway through competitively binding to microRNA-30a."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-021-02019-2"}], "href": "https://doi.org/10.1186/s12935-021-02019-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34238293"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34238293"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Naixiong Peng, Zejian Zhang, Yaomin Wang, et al. 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