{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00160 is an oncogenic long non‐coding RNA that plays multifaceted roles in cancer progression and drug resistance across different tumor types. In breast cancer, LINC00160 is up‐regulated in paclitaxel‐ and doxorubicin‐resistant cells where it promotes chemoresistance by recruiting the transcription factor C/EBPβ to the promoter of TFF3, thereby enhancing cell migration, invasion, and tumor growth, and correlates with a poor clinical response to paclitaxel."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In prostate cancer, LINC00160 is induced by STAT3 and acts as a transcriptional activator, epigenetically repressing RCAN1 through its association with EZH2. This results in increased proliferation, reduced apoptosis, and enhanced glycolysis, suggesting that LINC00160 contributes to tumor metabolism and progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In renal cell carcinoma, LINC00160 has been implicated in sunitinib resistance by recruiting TFAP2A to activate SAA1 expression. Elevated SAA1 not only facilitates drug efflux via its interaction with ABCB1, but also stimulates the JAK-STAT signaling pathway, thereby mitigating the anti-tumor effects of sunitinib."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, in estrogen receptor–positive breast cancer cells, LINC00160 is identified as a direct transcriptional target of ERα, and its silencing leads to a reduction in cellular proliferation, highlighting its potential as a novel biomarker for endocrine response and a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Huaiguo Wu, Juan Gu, Daoping Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00160 mediated paclitaxel-And doxorubicin-resistance in breast cancer cells by regulating TFF3 via transcription factor C/EBPβ."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.15487"}], "href": "https://doi.org/10.1111/jcmm.15487"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32652877"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32652877"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wenjing Zhu, Dongya Sheng, Yiqun Shao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STAT3-regulated LncRNA LINC00160 mediates cell proliferation and cell metabolism of prostate cancer cells by repressing RCAN1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-021-04284-1"}], "href": "https://doi.org/10.1007/s11010-021-04284-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35067783"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35067783"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Gong Cheng, Yuenan Liu, Lilong Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00160 mediates sunitinib resistance in renal cell carcinoma via SAA1 that is implicated in STAT3 activation and compound transportation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.103755"}], "href": "https://doi.org/10.18632/aging.103755"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32921632"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32921632"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Philip Jonsson, Cristian Coarfa, Fahmi Mesmar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Single-Molecule Sequencing Reveals Estrogen-Regulated Clinically Relevant lncRNAs in Breast Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2015-1153"}], "href": "https://doi.org/10.1210/me.2015-1153"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26426411"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26426411"}]}]}]}