{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00163 has emerged as a functionally versatile long non‐coding RNA with context‐dependent roles in cancer. In gastric cancer, for example, LINC00163 acts as a competing endogenous RNA that sponges microRNA‐183, thereby relieving inhibition of A‐Kinase Anchoring Protein 12 (AKAP12) and enhancing its tumor‐suppressive effects against invasion and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In bladder cancer, its altered expression is incorporated into a ceRNA network and is significantly associated with tumor grade, disease stage, and overall survival, implicating LINC00163 as a potential prognostic marker in the oncogenic process."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In papillary thyroid cancer, LINC00163 is upregulated and appears to promote cell proliferation, migration, and invasion by modulating the epithelial–mesenchymal transition, indicating an oncogenic role in this context."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Conversely, in lung cancer, LINC00163 is markedly downregulated, and its overexpression suppresses tumor cell proliferation as well as migration and invasion, thereby functioning as a tumor suppressor."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Collectively, these findings illustrate that LINC00163 may serve as both a prognostic biomarker and a therapeutic target, with its dualistic role in tumorigenesis being highly dependent on the specific cancer type.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jun Zhang, Hai-Yan Piao, Shuai Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00163 inhibits the invasion and metastasis of gastric cancer cells as a ceRNA by sponging miR-183 to regulate the expression of AKAP12."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10147-019-01604-w"}], "href": "https://doi.org/10.1007/s10147-019-01604-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31894433"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31894433"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhipeng Xu, Chuang Wang, Xuebao Xiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of mRNA Expression and Endogenous RNA Profiles in Bladder Cancer Based on The Cancer Genome Atlas (TCGA) Database."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.915487"}], "href": "https://doi.org/10.12659/MSM.915487"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31020952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31020952"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "P Gao, H Jiao, L Zhe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High expression of LINC0163 promotes progression of papillary thyroid cancer by regulating epithelial-mesenchymal transition MITF."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202005_21335"}], "href": "https://doi.org/10.26355/eurrev_202005_21335"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32495885"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32495885"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiaotong Guo, Youlei Wei, Zhe Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC00163 upregulation suppresses lung cancer development though transcriptionally increasing TCF21 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Cancer Res (2018)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30662806"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30662806"}]}]}]}