{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00165 has emerged as a regulatory non‐coding RNA with context‐dependent roles in human disease. In a genome‐wide association study investigating human narcolepsy, a candidate gene in the implicated region—initially designated NLC1‐A and now recognized as LINC00165—was found to harbor regulatory variants that significantly affect its expression in the hypothalamus, suggesting a protective effect against narcolepsy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, studies in gastric cancer have demonstrated that LINC00165 is upregulated in tumor tissues and cell lines, with its elevated expression correlating with advanced tumor stage, increased invasion depth, and poorer overall survival. Functional analyses revealed that LINC00165 promotes gastric cancer cell proliferation, migration, and invasion by serving as a scaffold to recruit Polycomb Repressive Complex 2, thereby facilitating the epithelial–mesenchymal transition. Moreover, its transcription is directly activated by STAT3 binding to its promoter region."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Minae Kawashima, Gen Tamiya, Akira Oka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genomewide association analysis of human narcolepsy and a new resistance gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1086/505539"}], "href": "https://doi.org/10.1086/505539"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16826516"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16826516"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yan Jin, Peng Wu, Wenjing Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC00165-induced by STAT3 exerts oncogenic properties via interaction with Polycomb Repressive Complex 2 to promote EMT in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.11.012"}], "href": "https://doi.org/10.1016/j.bbrc.2018.11.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30448060"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30448060"}]}]}]}