{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00184 has emerged as an oncogenic long noncoding RNA with multifaceted roles in tumor progression across several cancer types. In metastatic prostate cancer, LINC00184 promotes docetaxel resistance and immune escape by acting as a competing endogenous RNA that sequesters miR‐105‐5p, resulting in the upregulation of PD-L1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In cholangiocarcinoma, enhanced expression of LINC00184 contributes to cell proliferation, invasion, migration, and altered adenine metabolism by sponging miR‐23b‐3p, thereby relieving the repression of ANXA2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in non‐small cell lung cancer the overexpression of LINC00184 facilitates tumor cell proliferation, migration, invasion, cell cycle progression, and evasion of apoptosis through modulation of the miR‐524‐5p/HMGB2 axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In oesophageal squamous cell carcinoma, LINC00184 is associated with poor prognosis and enhanced glycolysis, with its expression being driven by STAT3 phosphorylated at serine 727 that translocates to the mitochondria."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, in esophageal cancer, LINC00184 contributes to metabolic reprogramming by recruiting DNMT1 to methylate the PTEN promoter, leading to Akt phosphorylation, increased glycolysis, and a concomitant reduction of mitochondrial oxidative phosphorylation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Finally, bioinformatic analyses in breast cancer have identified LINC00184 as a crucial component of a competing endogenous RNA network and a potent prognostic factor."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings demonstrate that LINC00184 exerts its oncogenic influence primarily by sponging specific microRNAs, thereby regulating downstream targets involved in immune evasion, chemotherapy resistance, cellular metabolism, and aggressive tumor behavior. This multifaceted role positions LINC00184 as a promising target for therapeutic intervention in various cancers.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wei Zhang, Jun Xin, Jinjin Lai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC00184 promotes docetaxel resistance and immune escape via miR-105-5p/PD-L1 axis in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunobiology (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.imbio.2021.152163"}], "href": "https://doi.org/10.1016/j.imbio.2021.152163"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34896914"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34896914"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hou-Bin Sun, Guang-Chen Zhang, Jia Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC00184 facilitates the proliferation, metastasis, and adenine metabolism of cholangiocarcinoma via modulating hsa-miR-23b-3p/ANXA2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Environ Toxicol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/tox.23154"}], "href": "https://doi.org/10.1002/tox.23154"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33913242"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33913242"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wuming Wang, Lin Li, Long Zhao "}, {"type": "b", "children": [{"type": "t", "text": "LINC00184 plays an oncogenic role in non-small cell lung cancer via regulation of the miR-524-5p/HMGB2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.16247"}], "href": "https://doi.org/10.1111/jcmm.16247"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34651416"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34651416"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yuwen Han, Jun You, Yun Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00184 Promotes Ovarian Cancer Cells Proliferation and Cisplatin Resistance by Elevating CNTN1 Expression via Sponging miR-1305."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S280490"}], "href": "https://doi.org/10.2147/OTT.S280490"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33907415"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33907415"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Weihao Li, Kai Huang, Fengbiao Wen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00184 silencing inhibits glycolysis and restores mitochondrial oxidative phosphorylation in esophageal cancer through demethylation of PTEN."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EBioMedicine (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ebiom.2019.05.055"}], "href": "https://doi.org/10.1016/j.ebiom.2019.05.055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31201145"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31201145"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yan Yao, Tingting Zhang, Lingyu Qi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated analysis of co-expression and ceRNA network identifies five lncRNAs as prognostic markers for breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.14721"}], "href": "https://doi.org/10.1111/jcmm.14721"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31613058"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31613058"}]}]}]}