LINC00189 Gene

Name long intergenic non-protein coding RNA 189
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00189 is a long non‐coding RNA that has recently been implicated in cancer progression through its association with adverse clinical outcomes. In a study of squamous cell carcinoma of the bladder, LINC00189 was identified as one of several hub genes within a co‐expression network, suggesting that it may participate in regulatory modules that contribute to intratumoral heterogeneity and possibly influence oncogenic signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, analysis in cervical cancer patients revealed that increased expression of LINC00189 was significantly associated with worse recurrence‐free survival, highlighting its potential utility as a prognostic biomarker and a candidate therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Although the precise molecular mechanisms through which LINC00189 functions remain to be fully elucidated, these findings collectively indicate that LINC00189 may play a critical role in tumor pathogenesis and recurrence across different cancer types.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaolong Zhang, Meng Zhang, Yong Hou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Single-cell analyses of transcriptional heterogeneity in squamous cell carcinoma of urinary bladder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.11803"}], "href": "https://doi.org/10.18632/oncotarget.11803"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27602771"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27602771"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yan Zhang, Xing Zhang, Haixia Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Potential Prognostic Long Non-Coding RNA Biomarkers for Predicting Recurrence in Patients with Cervical Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Manag Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/CMAR.S231796"}], "href": "https://doi.org/10.2147/CMAR.S231796"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32099468"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32099468"}]}]}]}
Synonyms C21ORF109, NCRNA00189
NCBI Gene ID 193629
API
Download Associations
Predicted Functions View LINC00189's ARCHS4 Predicted Functions.
Co-expressed Genes View LINC00189's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View LINC00189's ARCHS4 Predicted Functions.

Functional Associations

LINC00189 has 994 functional associations with biological entities spanning 7 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 26 datasets.

Click the + buttons to view associations for LINC00189 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray tissue samples with high or low expression of LINC00189 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00189 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of LINC00189 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of LINC00189 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of LINC00189 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00189 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
dbGAP Gene-Trait Associations traits associated with LINC00189 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at LINC00189 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of LINC00189 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of LINC00189 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of LINC00189 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of LINC00189 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of LINC00189 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of LINC00189 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of LINC00189 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of LINC00189 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of LINC00189 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
GWAS Catalog SNP-Phenotype Associations phenotypes associated with LINC00189 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.
GWASdb SNP-Disease Associations diseases associated with LINC00189 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.
GWASdb SNP-Phenotype Associations phenotypes associated with LINC00189 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of LINC00189 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00189 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain LINC00189 protein from the LOCATE Predicted Protein Localization Annotations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of LINC00189 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at LINC00189 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of LINC00189 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.