LINC00207 Gene

Name long intergenic non-protein coding RNA 207
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough the query requests a summary of the function of LINC00207, none of the provided abstracts mention or address LINC00207. Instead, these studies focus on the roles of miRNAs—particularly miR-207—in various cellular contexts. In one study, NK cell‐derived exosomal miRNAs are proposed to exert an antidepressant effect by modulating brain inflammatory processes, emphasizing how exosomal miRNA communication may underlie therapeutic mechanisms for depression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn another study, miR-207 is shown to be significantly upregulated in the myocardium and in neonatal mouse cardiac myocytes under type 2 diabetic cardiomyopathy conditions. Here, miR-207 directly targets LAMP2, resulting in autophagy inhibition and increased cardiomyocyte apoptosis, thereby contributing to the pathogenesis of diabetic cardiomyopathy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA further investigation highlights the role of miR-207 in enhancing ionizing radiation-induced apoptosis and DNA damage in auditory hair cells by directly targeting Akt3. This finding suggests that miR-207 modulates cellular sensitivity to radiation, opening potential avenues for protecting cochlea hair cells from radiation damage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while these abstracts provide valuable insights into miR-207’s involvement in modulating inflammation, autophagy, and apoptosis in diverse pathologies, they do not include any information on the function of LINC00207.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dongping Li, Ying Wang, Xinrong Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NK cell-derived exosomes carry miR-207 and alleviate depression-like symptoms in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neuroinflammation (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12974-020-01787-4"}], "href": "https://doi.org/10.1186/s12974-020-01787-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32321532"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32321532"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ruinan Xing, Dan Liu, Xiaoli Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-207 inhibits autophagy and promotes apoptosis of cardiomyocytes by directly targeting LAMP2 in type 2 diabetic cardiomyopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.09.092"}], "href": "https://doi.org/10.1016/j.bbrc.2019.09.092"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31564413"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31564413"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "P-x Tan, S-s Du, C Ren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-207 enhances radiation-induced apoptosis by directly targeting Akt3 in cochlea hair cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2014.407"}], "href": "https://doi.org/10.1038/cddis.2014.407"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25275594"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25275594"}]}]}]}
Synonyms NCRNA00207
NCBI Gene ID 388910
API
Download Associations
Predicted Functions View LINC00207's ARCHS4 Predicted Functions.
Co-expressed Genes View LINC00207's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View LINC00207's ARCHS4 Predicted Functions.

Functional Associations

LINC00207 has 885 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 21 datasets.

Click the + buttons to view associations for LINC00207 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of LINC00207 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00207 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of LINC00207 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of LINC00207 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores cellular components co-occuring with LINC00207 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00207 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene Mutation Profiles cell lines with LINC00207 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores diseases co-occuring with LINC00207 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at LINC00207 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of LINC00207 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of LINC00207 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing LINC00207 from the GeneSigDB Published Gene Signatures dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of LINC00207 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GWAS Catalog SNP-Phenotype Associations phenotypes associated with LINC00207 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of LINC00207 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00207 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain LINC00207 protein from the LOCATE Predicted Protein Localization Annotations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of LINC00207 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at LINC00207 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of LINC00207 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores tissues co-occuring with LINC00207 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.