{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00210 is a long noncoding RNA that exhibits oncogenic properties in multiple types of cancer. In nasopharyngeal carcinoma, it is upregulated and its overexpression is associated with enhanced cell proliferation, invasion, metastasis, and poor prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In osteosarcoma, LINC00210 is highly expressed and functions as a competing endogenous RNA by sponging miR‑342‑3p, thereby upregulating GFRA1 and reducing radiosensitivity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In non‑small cell lung cancer, studies have demonstrated that LINC00210 promotes cell proliferation and invasion by interacting with distinct microRNAs; one report shows that it modulates the miR‑16‑5p/PTK2 axis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", while another study indicates that it exerts its effects by sponging miR‑328‑5p, with corresponding influences on cell migration and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In liver cancer, LINC00210 is frequently amplified and highly expressed in tumor‐initiating cells, where it fosters self‑renewal and tumor initiation through activation of the Wnt/β‑catenin signaling pathway by binding CTNNBIP1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Similarly, in glioma, elevated LINC00210 levels correlate with advanced disease stage and poor prognosis, and loss‐of‑function studies reveal that its knockdown suppresses cell proliferation and migration via directly targeting miR‑328."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In thyroid cancer, LINC00210 overexpression enhances proliferation, migration, and invasion by acting as a sponge for miR‑195‑5p; this interaction alleviates the inhibition on IGF1R and activates the PI3K/Akt signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies indicate that LINC00210 contributes to tumorigenesis and cancer progression across diverse malignancies by modulating various signaling axes through microRNA sponging. Its impact on processes such as cell proliferation, invasion, metastasis, and therapy resistance makes it a promising candidate for future therapeutic targeting.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shu Zhang, Ping Li, Lei Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00210 as a miR-328-5p sponge promotes nasopharyngeal carcinoma tumorigenesis by activating NOTCH3 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20181168"}], "href": "https://doi.org/10.1042/BSR20181168"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30341249"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30341249"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Pan He, Yong-Qiang Xu, Zhi-Jun Wang, et al. 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