{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00211 appears to play distinct roles in lung adenocarcinoma pathogenesis. In one clinical report, a patient with ALK‐rearranged lung adenocarcinoma developed leptomeningeal metastases after initial treatment failure. Analysis of cerebrospinal fluid identified a novel LINC00211–ALK fusion that retained the ALK kinase domain. The detection of this fusion guided dose‐escalation strategies with alectinib and subsequent treatment with lorlatinib, ultimately leading to temporary disease control in the central nervous system, thereby illustrating a potential mechanism of treatment response based on the LINC00211 fusion partner."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In a separate study leveraging The Cancer Genome Atlas database, LINC00211 was identified among four long noncoding RNAs as differentially expressed in lung adenocarcinoma. Its expression was significantly associated with patient prognosis within a competing endogenous RNA network, suggesting that LINC00211 may also function as a regulatory molecule influencing tumor progression and clinical outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these studies suggest that LINC00211 contributes to lung adenocarcinoma both as a fusion partner capable of altering oncogenic ALK signaling in metastatic lesions and as a component of a broader regulatory network that impacts disease prognosis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhaona Li, Pupu Li, Bing Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sequential ALK inhibitor treatment benefits patient with leptomeningeal metastasis harboring non-EML4-ALK rearrangements detected from cerebrospinal fluid: A case report."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thorac Cancer (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1759-7714.13259"}], "href": "https://doi.org/10.1111/1759-7714.13259"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31766077"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31766077"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Huaihui Tang, Zhongshuai Wang, Qianqian Shao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive Analysis of Competing Endogenous RNA (ceRNA) Network Based on RNAs Differentially Expressed in Lung Adenocarcinoma Using The Cancer Genome Atlas (TCGA) Database."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.922676"}], "href": "https://doi.org/10.12659/MSM.922676"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32533823"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32533823"}]}]}]}