{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00216 functions as a tumor‐suppressive long noncoding RNA in gastric cancer by modulating key post‐transcriptional events that limit cancer progression. In gastric cancer tissues its expression is down‐regulated and low levels correlate with advanced tumor status, later clinical stages, and poor prognosis. Functional studies reveal that overexpression of LINC00216 suppresses cell invasion and metastasis by inhibiting the epithelial–mesenchymal transition (EMT). Mechanistically, LINC00216 directly interacts with the EMT regulator Slug and decreases its protein stability by enhancing the interaction between Slug and GSK3β, thereby promoting Slug degradation. Such regulation of a critical EMT factor highlights the role of LINC00216 as a pivotal modulator in post‐transcriptional control within the broader context of noncoding RNA‐mediated gene regulation in cancer biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yingcong Yu, Linjin Li, Zhiqiang Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA linc00261 suppresses gastric cancer progression via promoting Slug degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.13035"}], "href": "https://doi.org/10.1111/jcmm.13035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27878953"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27878953"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wenjing Liu, Rui Ma, Yuan Yuan "}, {"type": "b", "children": [{"type": "t", "text": "Post-transcriptional Regulation of Genes Related to Biological Behaviors of Gastric Cancer by Long Noncoding RNAs and MicroRNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/jca.22076"}], "href": "https://doi.org/10.7150/jca.22076"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29187891"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29187891"}]}]}]}