{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long noncoding RNAs (lncRNAs) have emerged as critical regulators of cellular processes underlying aging, bone homeostasis, and cancer. While previous studies have underscored the roles of transcription factors and gene regulatory networks in longevity (1) and bone mineral density regulation through components of the Wnt signaling pathway (2), recent evidence reveals that the lncRNA LINC00222 functions as a tumor suppressor in lung adenocarcinoma (3). In lung adenocarcinoma tissues, LINC00222 is significantly downregulated compared to adjacent normal lung tissues. Functional assays demonstrated that restoration of LINC00222 expression markedly inhibits cell proliferation, migration, and invasion, while also promoting apoptosis. Furthermore, overexpression of LINC00222 enhances the activity of glycogen synthase kinase-3β (GSK3β), implicating modulation of the Wnt signaling pathway as an underlying mechanism. Collectively, these findings position LINC00222 as a promising prognostic biomarker and potential therapeutic target in lung adenocarcinoma."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Timothy A Donlon, Brian J Morris, Randi Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FOXO3 longevity interactome on chromosome 6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging Cell (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/acel.12625"}], "href": "https://doi.org/10.1111/acel.12625"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28722347"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28722347"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Benjamin H Mullin, John P Walsh, Hou-Feng Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study using family-based cohorts identifies the WLS and CCDC170/ESR1 loci as associated with bone mineral density."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12864-016-2481-0"}], "href": "https://doi.org/10.1186/s12864-016-2481-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26911590"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26911590"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hongyan Zhang, Yuan Wang, Jibin Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC00222 regulates GSK3β activity and promotes cell apoptosis in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2018.06.165"}], "href": "https://doi.org/10.1016/j.biopha.2018.06.165"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29990868"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29990868"}]}]}]}