{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA LINC00226 has emerged as a potential regulatory molecule implicated in diverse biological processes and diseases. In penile cancer, LINC00226 is mapped to genomic regions that are frequently affected by copy number alterations at human papillomavirus (HPV) integration sites, suggesting that alterations in its dosage or regulation could contribute to the epigenetic and transcriptional dysregulation underlying tumor development and progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in chronic lymphocytic leukemia, LINC00226 is located within chromosomal segments that undergo deletions in a subset of cases, indicating that changes in this lncRNA’s genomic context might be associated with disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of human male germ cells, expression analyses across multiple studies have consistently identified LINC00226 as differentially expressed, highlighting its potential involvement in spermatogenesis and germ cell function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Furthermore, in pancreatic ductal adenocarcinoma, LINC00226 was among a set of lncRNAs that exhibited aberrant expression when comparing tumor cells to normal cells, suggesting that it may serve as a molecular marker or play a role in the cellular processes driving tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings support a role for LINC00226 in modulating gene expression and cellular pathways through its altered copy number or expression levels in both oncologic and reproductive contexts. However, the precise molecular mechanisms by which LINC00226 contributes to disease development and progression remain to be fully elucidated.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Juliana Macedo, Elis Silva, Leudivan Nogueira, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genomic profiling reveals the pivotal role of hrHPV driving copy number and gene expression alterations, including mRNA downregulation of TP53 and RB1 in penile cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.23185"}], "href": "https://doi.org/10.1002/mc.23185"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32212199"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32212199"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Rachel A Harris, Jadd M Stevens, Diane L Pickering, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frequency, variations, and prognostic implications of chromosome 14q32 deletions in chronic lymphocytic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leuk Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.leukres.2021.106665"}], "href": "https://doi.org/10.1016/j.leukres.2021.106665"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34293710"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34293710"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Meghali Joshi, Singh Rajender "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNAs (lncRNAs) in spermatogenesis and male infertility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Biol Endocrinol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12958-020-00660-6"}], "href": "https://doi.org/10.1186/s12958-020-00660-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33126901"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33126901"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiang Yu, Yang Lin, Wu Sui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of distinct long noncoding RNA transcriptional fingerprints in pancreatic ductal adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.1027"}], "href": "https://doi.org/10.1002/cam4.1027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28220683"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28220683"}]}]}]}