{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a study evaluating differentially expressed long noncoding RNAs (lncRNAs) in lung tissues from patients with chronic obstructive pulmonary disease (COPD) versus non-COPD controls, LINC00229 was identified as one of the five significantly down‐regulated lncRNAs (1). Although the primary focus of the research was to investigate the role of lncRNA TUG1 in mediating cellular proliferation and fibrotic responses under TGF-β treatment, the marked decrease in LINC00229 expression in COPD lung tissues suggests that it may be involved in the deregulation of molecular pathways associated with the disease. Its differential expression highlights the potential utility of LINC00229, alongside other lncRNAs, as a biomarker for COPD diagnosis and possibly as a contributor to disease pathogenesis by reflecting alterations in pulmonary cellular functions."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wenxiang Tang, Zhenyu Shen, Jiang Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Screening of long non-coding RNA and TUG1 inhibits proliferation with TGF-β induction in patients with COPD."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Chron Obstruct Pulmon Dis (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/COPD.S109570"}], "href": "https://doi.org/10.2147/COPD.S109570"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27932875"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27932875"}]}]}]}