LINC00238 Gene

Name long intergenic non-protein coding RNA 238
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‑coding RNA LINC00238 functions as a tumor suppressor in hepatocellular carcinoma by inhibiting several key malignant phenotypes. Specifically, LINC00238 is significantly downregulated in liver cancer tissues, and its restoration results in decreased cell viability, migration, and invasion, while promoting apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Mechanistic studies indicate that LINC00238 negatively regulates the expression of transmembrane protein TMEM106C, which otherwise acts to suppress the apoptosis pathway by reducing the levels of pro‐apoptotic molecules such as caspase‑7, tissue inhibitor of metalloproteinase‑2, programmed cell death‑4, and activating transcription factor 3 (ATF3). Intriguingly, ATF3 also appears to act upstream as a positive regulator of LINC00238, suggesting the existence of a regulatory feedback loop that contributes to the inhibition of tumor progression in hepatocellular carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hong-Gang Qian, Qiong Wu, Jian-Hui Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non‑coding RNA LINC00238 suppresses the malignant phenotype of liver cancer by sponging miR‑522."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2022.12587"}], "href": "https://doi.org/10.3892/mmr.2022.12587"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35014686"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35014686"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Caihua Jiang, Feng Li, Meng Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00238 inhibits hepatic carcinoma progression by activating TMEM106C‑mediated apoptosis pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2021.12397"}], "href": "https://doi.org/10.3892/mmr.2021.12397"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34476506"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34476506"}]}]}]}
Synonyms CCDC196, NCRNA00238, C14ORF53
NCBI Gene ID 440184
API
Download Associations
Predicted Functions View LINC00238's ARCHS4 Predicted Functions.
Co-expressed Genes View LINC00238's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View LINC00238's ARCHS4 Predicted Functions.

Functional Associations

LINC00238 has 704 functional associations with biological entities spanning 7 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 25 datasets.

Click the + buttons to view associations for LINC00238 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of LINC00238 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray tissue samples with high or low expression of LINC00238 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of LINC00238 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00238 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of LINC00238 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of LINC00238 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00238 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at LINC00238 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of LINC00238 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of LINC00238 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of LINC00238 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of LINC00238 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of LINC00238 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of LINC00238 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of LINC00238 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of LINC00238 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of LINC00238 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00238 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain LINC00238 protein from the LOCATE Predicted Protein Localization Annotations dataset.
MiRTarBase microRNA Targets microRNAs targeting LINC00238 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of LINC00238 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of LINC00238 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations gene perturbations changing expression of LINC00238 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at LINC00238 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of LINC00238 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.