{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00240 is a long non‐coding RNA that has emerged as an important regulator in multiple pathological conditions, particularly in various cancers, by acting predominantly as a competing endogenous RNA (ceRNA) that sponges specific microRNAs. In cervical cancer, for example, LINC00240 is markedly upregulated and promotes tumor growth, migration, and invasion through sequestering miR‐124-3p, which leads to enhanced STAT3 expression and subsequent suppression of antitumor immune responses mediated by natural killer T cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in lung cancer, LINC00240 functions as a molecular sponge for miR‐7-5p, resulting in the derepression of EGFR and thereby stimulating cell invasion and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In gastric cancer, studies have revealed that elevated LINC00240 expression is associated with advanced disease features. It exerts its oncogenic role by modulating different axes – one study demonstrated that LINC00240 sponges miR‐338-5p, leading to increased METTL3 expression and consequently promoting cell proliferation and migration"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", while another highlighted a LINC00240/miR‐124-3p/DNMT3B (or miR‐99a-5p/IGF1R) axis contributing to gastric tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In hepatocellular carcinoma, LINC00240 is upregulated and facilitates cell viability, migration, and invasion by sponging miR‐4465, thereby activating the HGF/c-MET signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In nasopharyngeal carcinoma, high LINC00240 levels contribute to enhanced proliferation, invasion, migration, and angiogenesis by sequestering miR‐26a-5p, which in turn leads to the upregulation of EZH2 and modulation of cell cycle regulators."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond these oncological settings, LINC00240 has also been implicated in other pathological conditions. In intervertebral disc degeneration, although data are more limited and partly complicated by nomenclature discrepancies, knockdown studies suggest that modulating LINC00240 may affect nucleus pulposus cell proliferation and apoptosis, hinting at a potential role in spinal degeneration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In esophageal squamous cell carcinoma, disruption of the miR‐26b-mediated crosstalk involving LINC00240 has been associated with altered extracellular matrix interactions and wound response, reflecting its broader regulatory function as a ceRNA."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Furthermore, in the context of endometrial receptivity, LINC00240 is part of a ceRNA network with miR‐182 and NDRG1, which may be critical for successful embryo implantation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", and it has also been identified as a potential biomarker in ischemic stroke."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings underscore that LINC00240 functions primarily as an oncogenic regulator and a potential biomarker by sponging various microRNAs to modulate key signaling pathways involved in cellular proliferation, migration, invasion, and apoptosis across different disease contexts, thereby representing an attractive target for future therapeutic interventions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yan Zhang, Xing Li, Jun Zhang, et al. 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