{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00242 has emerged as a multifunctional long non‐coding RNA that primarily exerts oncogenic functions across several disease contexts. In gastric cancer, LINC00242 is highly expressed and promotes tumorigenesis by enhancing aerobic glycolysis and cell proliferation. Mechanistically, one study demonstrated that LINC00242 acts as a competing endogenous RNA (ceRNA) by binding to miR‑1‑3p and thereby upregulating G6PD, which facilitates the Warburg effect and tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In a separate investigation on gastric cancer, LINC00242 was shown to interact with miR‑141, leading to the upregulation of FOXC1, with consequent enhancements in cell viability, migration, invasion, and angiogenic potential, further underpinning its tumor‐promoting role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond gastric cancer, LINC00242 has also been identified as a key enhancer RNA in pancreatic adenocarcinoma. Its expression strongly correlates with that of its target gene, PHF10, and alterations in LINC00242 levels are associated with distinct clinicopathological features and variations in immune cell infiltration, suggesting that it modulates the tumor microenvironment and patient prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, in the context of spondyloarthropathy/ankylosing spondylitis, LINC00242 was identified as one of the hub long non‑coding RNAs within a competitive regulatory network that impacts critical signaling sub‑pathways, including those in the MAPK, chemokine, and HIF‑1 pathways. This finding implies that beyond its oncogenic role, LINC00242 may also contribute to inflammatory processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, LINC00242 predominantly functions as an oncogenic regulator through its activity as a molecular sponge for specific microRNAs. This interaction relieves microRNA‐mediated repression of downstream targets—such as G6PD, FOXC1, and PHF10—thereby promoting enhanced aerobic glycolysis, cellular proliferation, metastasis, and even modulating the immune milieu. These multifaceted roles highlight LINC00242 as a promising candidate for therapeutic targeting in various cancers and potentially in inflammatory conditions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Peng Deng, Kai Li, Feng Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00242/miR-1-3p/G6PD axis regulates Warburg effect and affects gastric cancer proliferation and apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s10020-020-00259-y"}], "href": "https://doi.org/10.1186/s10020-020-00259-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33514309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33514309"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiongdong Zhong, Xianchang Yu, Xiaoyan Wen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of the LINC00242/miR-141/FOXC1 axis underpins the development of gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-020-01369-7"}], "href": "https://doi.org/10.1186/s12935-020-01369-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32587479"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32587479"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wen Tong, Liuyang Zhu, Yi Bai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhancer RNA LINC00242-Induced Expression of PHF10 Drives a Better Prognosis in Pancreatic Adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2021.795090"}], "href": "https://doi.org/10.3389/fonc.2021.795090"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35127503"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35127503"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ming Ding, Ting-Jin Guan, Chuan-Yin Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of pathways significantly associated with spondyloarthropathy/ankylosing spondylitis using the sub‑pathway method."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.9395"}], "href": "https://doi.org/10.3892/mmr.2018.9395"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30132545"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30132545"}]}]}]}