{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In neuroblastoma, the long noncoding RNA LINC00260 has been identified as one of the key immune‐related lncRNAs contributing to a prognostic risk signature. This signature, which also includes several other lncRNAs and immune‐related genes, was developed to stratify patients based on overall and event/progression‐free survival (1). Elevated expression of the lncRNA signature, with LINC00260 as a component, is associated with a shorter survival time and correlates with a distinct immune microenvironment—specifically, a negative association with activated dendritic cells and CD8+ T cells and a positive association with Th2 cells. Functional enrichment analyses further suggest that these lncRNAs, including LINC00260, are involved in key cancer-related and immune pathways that may influence neuroblastoma progression. These findings offer new insights that could eventually guide the optimization of treatment strategies in neuroblastoma (1)."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaodan Zhong, Ying Tao, Jian Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic Signature of Immune Genes and Immune-Related LncRNAs in Neuroblastoma: A Study Based on GEO and TARGET Datasets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2021.631546"}], "href": "https://doi.org/10.3389/fonc.2021.631546"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33767996"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33767996"}]}]}]}