LINC00272 Gene

Name long intergenic non-protein coding RNA 272
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a genome‐wide association study of familial hepatitis B virus–related hepatocellular carcinoma (HCC) (PMID:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", a haplotype block at 1q25.3 was identified that encompasses several genes, including the long intergenic non‐protein-coding RNA LINC00272. Although the study primarily highlighted associated haplotypes in GLUL and other nearby genes, the inclusion of LINC00272 suggests that this long noncoding RNA may contribute to the genetic susceptibility observed in familial HBV-related HCC. The precise functional role of LINC00272 in hepatocarcinogenesis remains to be elucidated, but its presence in this locus implies a potential regulatory or modulatory role in liver tumor development. Notably, LINC00272 does not appear to have been implicated in the other investigated contexts, such as cervical pre-cancer progression (PMID:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "or salivary gland carcinoma risk (PMID:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", indicating that its contribution may be specific to the pathogenesis of familial HBV-related HCC.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "You-Yu Lin, Ming-Whei Yu, Shi-Ming Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association analysis identifies a GLUL haplotype for familial hepatitis B virus-related hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cncr.30851"}], "href": "https://doi.org/10.1002/cncr.30851"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28662289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28662289"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kathryn E Royse, Degui Zhi, Michael G Conner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential Gene Expression Landscape of Co-Existing Cervical Pre-Cancer Lesions Using RNA-seq."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2014.00339"}], "href": "https://doi.org/10.3389/fonc.2014.00339"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25505737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25505737"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Li Xu, Hongwei Tang, Diane W Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study identifies common genetic variants associated with salivary gland carcinoma and its subtypes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cncr.29381"}], "href": "https://doi.org/10.1002/cncr.29381"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25823930"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25823930"}]}]}]}
Synonyms C1ORF120, NCRNA00272
NCBI Gene ID 388719
API
Download Associations
Predicted Functions View LINC00272's ARCHS4 Predicted Functions.
Co-expressed Genes View LINC00272's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View LINC00272's ARCHS4 Predicted Functions.

Functional Associations

LINC00272 has 278 functional associations with biological entities spanning 5 categories (molecular profile, chemical, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 15 datasets.

Click the + buttons to view associations for LINC00272 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00272 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of LINC00272 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of LINC00272 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00272 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at LINC00272 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of LINC00272 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of LINC00272 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of LINC00272 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of LINC00272 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of LINC00272 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of LINC00272 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00272 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain LINC00272 protein from the LOCATE Predicted Protein Localization Annotations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of LINC00272 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at LINC00272 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.