{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00276, a long non‐coding RNA, has been implicated in diverse pathological contexts. Although it was not specifically highlighted individually in osteoarthritis studies, global lncRNA profiling in osteoarthritis revealed widespread dysregulation affecting processes such as immune response, transcription regulation, and signal transduction (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In colorectal cancer, LINC00276 emerged as one of six lncRNAs employed to construct a prognostic signature, with its altered expression correlating with cancer‐related pathways and disease‐free survival outcomes (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, in the context of genomic amplification in solid tumors—specifically neuroblastoma—a fusion transcript involving LINC00276 (annotated as NCRNA00276) was detected alongside MYCN amplification, suggesting a potential, albeit yet to be clearly defined, role in tumorigenesis (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lei Chen, Yingqi Zhang, Zhitao Rao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated analysis of key mRNAs and lncRNAs in osteoarthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Ther Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/etm.2018.6360"}], "href": "https://doi.org/10.3892/etm.2018.6360"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30186409"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30186409"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jian Zhao, Jian Xu, An-Quan Shang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Six-LncRNA Expression Signature Associated with Prognosis of Colorectal Cancer Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000494868"}], "href": "https://doi.org/10.1159/000494868"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30396175"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30396175"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Clelia Tiziana Storlazzi, Angelo Lonoce, Maria C Guastadisegni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene amplification as double minutes or homogeneously staining regions in solid tumors: origin and structure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gr.106252.110"}], "href": "https://doi.org/10.1101/gr.106252.110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20631050"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20631050"}]}]}]}