{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00278 is a Y‐linked long non‐coding RNA that has emerged as an important molecular modulator in certain cancers. In laryngeal squamous cell carcinoma, low expression of LINC00278 is associated with advanced tumor stage, lymphatic metastasis, and poorer pathological differentiation. Functional studies revealed that overexpression of LINC00278 significantly suppresses tumor cell proliferation, migration, and invasion. This suppression is achieved in part by altering key markers of the epithelial–mesenchymal transition—upregulating E‐cadherin while downregulating N‐cadherin, Vimentin, Zeb1, and Snail—and by inhibiting the AKT/mTOR signaling pathway via the downregulation of COL4A1 and COL4A2. Importantly, the transcription factor ETS1 directly binds to the LINC00278 promoter to regulate its expression, and in a feedback manner, high LINC00278 levels inhibit ETS1 expression and phosphorylation."}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, emerging evidence in esophageal squamous cell carcinoma suggests that Y‐linked lncRNAs such as LINC00278 may also encode functional micropeptides, indicating additional layers of biological activity in tumorigenesis. More broadly, high‐throughput transcriptomic studies in neonatal blood spots, first‐trimester placentas, and in the context of respiratory viral infections have underscored the significance of sex‐specific gene expression patterns. These studies provide supportive context for investigating the biological impact of Y‐linked transcripts like LINC00278 on development, disease, and sexual dimorphism."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chuan Yang, Huan Cao, Jian-Wang Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ETS1-LINC00278 negative feedback loop plays a role in COL4A1/COL4A2 regulation in laryngeal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasma (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4149/neo_2022_220310N263"}], "href": "https://doi.org/10.4149/neo_2022_220310N263"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35532293"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35532293"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jonas Bybjerg-Grauholm, Christian Munch Hagen, Sok Kean Khoo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNA sequencing of archived neonatal dried blood spots."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Metab Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymgmr.2016.12.004"}], "href": "https://doi.org/10.1016/j.ymgmr.2016.12.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28053876"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28053876"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tania L Gonzalez, Tianyanxin Sun, Alexander F Koeppel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sex differences in the late first trimester human placenta transcriptome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Sex Differ (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13293-018-0165-y"}], "href": "https://doi.org/10.1186/s13293-018-0165-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29335024"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29335024"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ruchir Gupta, Mara L Leimanis, Marie Adams, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Balancing precision versus cohort transcriptomic analysis of acute and recovery phase of viral bronchiolitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Lung Cell Mol Physiol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajplung.00440.2020"}], "href": "https://doi.org/10.1152/ajplung.00440.2020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33851876"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33851876"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Siqi Wu, Liyuan Zhang, Jieqiong Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Novel Micropeptide Encoded by Y-Linked LINC00278 Links Cigarette Smoking and AR Signaling in Male Esophageal Squamous Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-19-3440"}], "href": "https://doi.org/10.1158/0008-5472.CAN-19-3440"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32169859"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32169859"}]}]}]}