{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00290 is a long intergenic noncoding RNA that has emerged as a candidate gene with potential roles in both oncogenic processes and tissue-specific inflammatory responses. A genetic variant located near LINC00290 was found to exhibit a significant sex‐specific association with cerebrospinal fluid amyloid‐β42 levels, suggesting that this lncRNA locus may contribute to molecular pathways underlying neurodegenerative endophenotypes, particularly in Alzheimer’s disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the context of cancer, especially cervical carcinogenesis, HPV DNA integration events have been shown to dysregulate LINC00290, with transcriptomic analyses implicating it as a potential driver gene."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, integrated analyses in pulpitis have identified LINC00290 as a component of a competing endogenous RNA network associated with inflammation, positioning it as a promising diagnostic biomarker for this condition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In pediatric adrenocortical tumors, focal deletions in the genomic region containing LINC00290 further suggest that loss or deregulation of this lncRNA may play a role in tumorigenesis, potentially acting as a tumor suppressor or influencing oncogenic pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuetiva Deming, Logan Dumitrescu, Lisa L Barnes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sex-specific genetic predictors of Alzheimer's disease biomarkers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Neuropathol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00401-018-1881-4"}], "href": "https://doi.org/10.1007/s00401-018-1881-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29967939"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29967939"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Liyuan Zhou, Qiongzi Qiu, Qing Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-022-30190-1"}], "href": "https://doi.org/10.1038/s41467-022-30190-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35538075"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35538075"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Liu Liu, Tianyi Wang, Dingming Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive Analysis of Differentially Expressed Genes in Clinically Diagnosed Irreversible Pulpitis by Multiplatform Data Integration Using a Robust Rank Aggregation Approach."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Endod (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.joen.2021.07.007"}], "href": "https://doi.org/10.1016/j.joen.2021.07.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34260959"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34260959"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Eric Letouzé, Roberto Rosati, Heloisa Komechen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNP array profiling of childhood adrenocortical tumors reveals distinct pathways of tumorigenesis and highlights candidate driver genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2012-1184"}], "href": "https://doi.org/10.1210/jc.2012-1184"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22539591"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22539591"}]}]}]}