LINC00294 Gene

Name long intergenic non-protein coding RNA 294
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00294 functions as an important regulatory long noncoding RNA in multiple tumor types. In glioma, LINC00294 is markedly downregulated compared to normal brain tissues. Its overexpression suppresses glioma cell proliferation and promotes apoptosis through distinct mechanisms: one involves sponging miR‐1278 to relieve the inhibition on the tumor suppressor neurofilament medium (NEFM), and another involves sequestering miR‐21‑5p to elevate CASKIN1 levels and subsequently activate the cAMP signaling pathway, which in turn disrupts mitochondrial function and enhances apoptosis under hypoxic conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In cervical cancer, however, LINC00294 is induced by glucose‑regulated protein 78 (GRP78) and appears to promote tumor progression. Knockdown of LINC00294 in cervical cancer cells results in cell cycle arrest at the G0/G1 phase, downregulation of cyclin D, cyclin E, and CDK4, upregulation of the inhibitors p16 and p21, and suppression of the Hedgehog signaling pathway, indicating its role in driving cell cycle progression and tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaokun Zhou, Liang Lv, Zhongyi Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00294 negatively modulates cell proliferation in glioma through a neurofilament medium-mediated pathway via interacting with miR-1278."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gene Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jgm.3235"}], "href": "https://doi.org/10.1002/jgm.3235"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32450002"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32450002"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaogang Dong, Qin Pi, Anwaier Yuemaierabola, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing LINC00294 Restores Mitochondrial Function and Inhibits Apoptosis of Glioma Cells under Hypoxia via the miR-21-5p/CASKIN1/cAMP Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oxid Med Cell Longev (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/8240015"}], "href": "https://doi.org/10.1155/2021/8240015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34777696"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34777696"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jiangnan Qiu, Shulin Zhou, Wenjun Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00294 induced by GRP78 promotes cervical cancer development by promoting cell cycle transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2020.12125"}], "href": "https://doi.org/10.3892/ol.2020.12125"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32989396"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32989396"}]}]}]}
Synonyms NCRNA00294
NCBI Gene ID 283267
API
Download Associations
Predicted Functions View LINC00294's ARCHS4 Predicted Functions.
Co-expressed Genes View LINC00294's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View LINC00294's ARCHS4 Predicted Functions.

Functional Associations

LINC00294 has 493 functional associations with biological entities spanning 6 categories (molecular profile, organism, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 19 datasets.

Click the + buttons to view associations for LINC00294 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of LINC00294 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of LINC00294 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00294 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of LINC00294 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00294 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at LINC00294 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of LINC00294 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of LINC00294 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of LINC00294 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of LINC00294 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of LINC00294 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of LINC00294 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of LINC00294 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of LINC00294 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GTEx Tissue-Specific Aging Signatures tissue samples with high or low expression of LINC00294 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of LINC00294 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00294 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of LINC00294 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at LINC00294 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.