{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent whole‐genome sequencing studies in family‐based cohorts of Alzheimer’s disease (AD) cases have identified 13 novel candidate loci, including "}, {"type": "b", "children": [{"type": "t", "text": "LINC00298"}]}, {"type": "t", "text": ", as rare‐variant risk factors (1,2). In these investigations, both single-variant and spatial clustering–based analyses revealed that variants in LINC00298 and the other novel loci were consistently associated with AD risk in discovery and replication cohorts (1,2). Notably, follow‐up analyses implicated these genes in synaptic function—a finding that differs from the common AD-associated variants, which are predominantly linked to innate immunity and, in some cases, amyloid processing (1,2). These findings underscore the potential role of non-coding RNAs such as LINC00298 in the genetic architecture of AD, highlighting the value of whole-genome sequencing approaches to uncover disease-associated rare variants outside of coding regions."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dmitry Prokopenko, Sarah L Morgan, Kristina Mullin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Whole-genome sequencing reveals new Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Alzheimers Dement (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/alz.12319"}], "href": "https://doi.org/10.1002/alz.12319"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33797837"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33797837"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Dmitry Prokopenko, Sarah L Morgan, Kristina Mullin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Whole-genome sequencing reveals new Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "medRxiv (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/2020.11.03.20225540"}], "href": "https://doi.org/10.1101/2020.11.03.20225540"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33173892"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33173892"}]}]}]}